An anticancer agent
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Labeled Version(s)
44406Mertansine-13C-d3
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Product Type

Biochemicals

Research Area

Cancer
Cell Death

Mertansine

Item No. 22483

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2′-deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine
CAS Number
139504-50-0
Synonyms
  • DM1
  • Emtansine
Molecular Formula
C35H48ClN3O10S
Formula Weight
738.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMF:PBS (pH7.2) (1:30): 0.03 mg/mlDMSO: 20 mg/mlEthanol: 0.25 mg/ml
λmax
233, 253 nm
SMILES
C[C@@]1([C@@H](O1)[C@H](C)[C@]([H])(C[C@](N2)(O)[C@]([H])(OC)/C=C/C=C(CC3=CC(OC)=C(Cl)C4=C3)\C)OC2=O)[C@@]([H])(OC([C@@H](N(C)C(CCS)=O)C)=O)CC(N4C)=O
InChi Code
InChI=1S/C35H48ClN3O10S/c1-19-10-9-11-26(46-8)35(44)18-25(47-33(43)37-35)20(2)31-34(4,49-31)27(48-32(42)21(3)38(5)28(40)12-13-50)17-29(41)39(6)23-15-22(14-19)16-24(45-7)30(23)36/h9-11,15-16,20-21,25-27,31,44,50H,12-14,17-18H2,1-8H3,(H,37,43)/b11-9+,19-10+/t20-,21+,25+,26-,27+,31+,34+,35+/m1/s1
InChi Key
ANZJBCHSOXCCRQ-FKUXLPTCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $183

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    25 mg

    $402

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    Cayman Chemical
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    Product Description

    Mertansine is a thiol-containing derivative of maytansine that is cytotoxic to human epidermoid carcinoma KB and human breast cancer SK-BR-3 cells (IC50 = 1.10 nM for both).1 Formulations containing mertansine have been studied for the treatment of multiple myeloma and squamous cell carcinoma.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Widdison, W.C., Wilhelm, S.D., Cavanagh, E.E., et al. Semisynthetic maytansine analogues for the targeted treatment of cancer. J. Med. Chem. 49(14), 4392-4408 (2006).

    2. Berdeja, J.G. Lorvotuzumab mertansine: Antibody-drug-conjugate for CD56+ multiple myeloma. Front. Biosci. 19(1), 163-170 (2014).

    3. Tijink, B.M., Buter, J., de Bree, R., et al. A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus. Clin. Cancer Res. 12(20 Pt 1), 6064-6072 (2006).