An internal standard for the quantification of mertansine
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Unlabeled Version(s)
22483Mertansine
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Mertansine-13C-d3

Item No. 44406

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-(3-mercaptopropanoyl)-N-(methyl-13C-d3)-L-alaninate
Synonyms
  • DM1-13C-d3
  • Emtansine-13C-d3
Molecular Formula
C34[13C]H45D3ClN3O10S
Formula Weight
742.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly solubleMethanol: Slightly soluble
SMILES
C[C@@]1([C@@H](O1)[C@H](C)[C@]([H])(C[C@](N2)(O)[C@H](OC)/C=C/C=C(CC3=CC(OC)=C(Cl)C4=C3)\C)OC2=O)[C@@]([H])(OC([C@@H](N([13C]([2H])([2H])[2H])C(CCS)=O)C)=O)CC(N4C)=O
InChi Code
InChI=1S/C35H48ClN3O10S/c1-19-10-9-11-26(46-8)35(44)18-25(47-33(43)37-35)20(2)31-34(4,49-31)27(48-32(42)21(3)38(5)28(40)12-13-50)17-29(41)39(6)23-15-22(14-19)16-24(45-7)30(23)36/h9-11,15-16,20-21,25-27,31,44,50H,12-14,17-18H2,1-8H3,(H,37,43)/b11-9+,19-10+/t20-,21+,25+,26-,27+,31+,34+,35+/m1/s1/i5+1D3
InChi Key
ANZJBCHSOXCCRQ-FDFSHFCXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $605

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    Product Description

    Mertansine-13C-d3 is intended for use as an internal standard for the quantification of mertansine (Item No. 22483) by GC- or LC-MS. Mertansine is a synthetic maytansinoid antimitotic agent.1,2 It is cytotoxic to KB epidermoid carcinoma and SK-BR-3 breast cancer cells (IC50 = 1.1 nM for both).1 Mertansine has commonly been used as a payload in antibody-drug conjugates (ADCs) that selectively target cancer cells in vitro and in animal models.3,4,5 Formulations containing mertansine conjugated to ado-trastuzumab have been used in the treatment of HER2+ breast cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Widdison, W.C., Wilhelm, S.D., Cavanagh, E.E., et al. Semisynthetic maytansine analogues for the targeted treatment of cancer. J. Med. Chem. 49(14), 4392-4408 (2006).

    2. Lopus, M. Antibody-DM1 conjugates as cancer therapeutics. Cancer Lett. 307(2), 113-115 (2011).

    3. Berdeja, J.G. Lorvotuzumab mertansine: Antibody-drug-conjugate for CD56+ multiple myeloma. Front. Biosci. 19(1), 163-170 (2014).

    4. Mckertish, C.M., and Kayser, V. A novel dual-payload ADC for the treatment of HER2+ breast and colon cancer. Pharmaceutics 15(8), 2020 (2023).

    5. Huhe, M., Lou, J., Zhu, Y., et al. A novel antibody-drug conjugate, HcHAb18-DM1, has potent anti-tumor activity against human non-small cell lung cancer. Biochem. Biophys. Res. Commun. 513(4), 1083-1091 (2019).