A bioactive sphingolipid
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Sphinganine-1-phosphate (d18:0)

Item No. 22500

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2(S)-amino-1,3(R)-octadecanediol, 1-(dihydrogen phosphate)
CAS Number
19794-97-9
Synonyms
  • C18-dihydro Sphingosine-1-phosphate
  • D-erythro-Sphinganine-1-phosphate
  • dihydro-D-erythro-Sphingosine-1-phosphate
Molecular Formula
C18H40NO5P
Formula Weight
381.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.3 M NaOH: 4 mg/mlDMF: <50 µg/mlDMSO: <50 µg/mlEthanol: <50 µg/mlPBS (pH 7.2): <50 µg/ml
SMILES
N[C@H]([C@H](O)CCCCCCCCCCCCCCC)COP(O)(O)=O
InChi Code
InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/t17-,18+/m0/s1
InChi Key
YHEDRJPUIRMZMP-ZWKOTPCHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $69

    Add

    1 mg

    $120

    Add

    5 mg

    $461

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Sphinganine-1-phosphate is an intermediate in the metabolism of glycosphingolipids and sphingolipids. It acts as an antagonist at the sphingosine-1-phosphate (S1P1/EDG-1) receptor (Ki = 15 nM).1 Sphinganine-1-phosphate prevents liver and kidney damage following hepatic ischemia and reperfusion injury in mice at doses lower than 0.1 and 0.2 mg/kg when administered prior to or following reperfusion, respectively.2 It has antifibrotic effects in scleroderma fibroblasts through normalization of PTEN protein levels, collagen and matrix metalloproteinase-1 (MMP-1) expression, and Smad3 phosphorylation.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Van Brocklyn, J.R., Lee, M.-J., Menzeleev, R., et al. Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. J. Cell. Biol. 142(1), 229-240 (1998).

    2. Park, S.W., Kim, M., Chen, S.W.C., et al. Sphinganine-1-phosphate attenuates both hepatic and renal injury induced by hepatic ischemia and reperfusion in mice. Shock 33(1), 31-42 (2010).

    3. Bu, S., Asano, Y., Bujor, A., et al. Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels. Arthrtis Rheum. 62(7), 2117-2126 (2010).

    4. Bu, S., Kapanadze, B., Hsu, T., et al. Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-β/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway. The Journal of Biological Chemisty 283(28), 19593-19602 (2008).

    Product Citations

    Lahey, L.J., Mardjuki, R.E., Wen, X., et al. LRRC8A:C/E heteromeric channels are ubiquitous transporters of cGAMP. Mol. Cell. 80(4), 578-591 (2020).