An internal standard for the quantification of losartan
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Losartan-d4

Item No. 22567

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl-2,3,5,6-d4]methyl]-1H-imidazole-5-methanol
CAS Number
1030937-27-9
Molecular Formula
C22H19ClD4N6O
Formula Weight
426.9
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 100 mM
SMILES
[H]N1N=NN=C1C2=CC=CC=C2C3=C([2H])C([2H])=C(CN4C(CO)=C(Cl)N=C4CCCC)C([2H])=C3[2H]
InChi Code
InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)/i9D,10D,11D,12D
InChi Key
PSIFNNKUMBGKDQ-IRYCTXJYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $134

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    1 mg

    $253

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    Product Description

    Losartan-d4 is intended for use as an internal standard for the quantification of losartan (potassium salt) (Item No. 10006594) by GC- or LC-MS. Losartan is an antagonist of the angiotensin (AT) II receptor subtype AT1 with a Ki value of 5-20 nM.1 It has an attenuating effect on vein graft atherosclerosis in rabbits and effectively reduces arterial blood pressure in rats.2,3 Formulations containing losartan have been used to control hypertension while protecting renal function.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ji, H., Leung, M., Zhang, Y., et al. Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartan. The Journal of Biological Chemisty 269(24), 16533-16536 (1994).

    2. Ge, J., Huang, D., Liang, C., et al. Upregulation of lectinlike oxidized low-density lipoprotein receptor-1 expression contributes to the vein graft atherosclerosis: Modulation by losartan. Atherosclerosis 177(2), 263-268 (2004).

    3. Xavier, F.E., Rossoni, L.V., Alonso, M.J., et al. Ouabain-induced hypertension alters the participation of enothelial factors in α-adrenergic responses differently in rat resistance and conductance mesenteric arteries. Br. J. Pharmacol. 143(1), 215-225 (2004).

    4. Caruso, D., D'Avino, M., Acampora, C., et al. Effects of losartan and chlorthalidone on blood pressure and renal vascular resistance index in non-diabetic patients with essential hypertension and normal renal functions. J. Cardiovasc. Pharmacol. 44(5), 520-524 (2004).