A degradation product of ibuprofen
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1-oxo Ibuprofen

Item No. 22573

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-methyl-4-(2-methyl-1-oxopropyl)-benzeneacetic acid
CAS Number
65813-55-0
Synonyms
  • Ibuprofen Impurity J
Molecular Formula
C13H16O3
Formula Weight
220.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: soluble
SMILES
CC(C(O)=O)C1=CC=C(C(C(C)C)=O)C=C1
InChi Code
InChI=1S/C13H16O3/c1-8(2)12(14)11-6-4-10(5-7-11)9(3)13(15)16/h4-9H,1-3H3,(H,15,16)
InChi Key
RCINGEKPKJQCMO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $135

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    10 mg

    $219

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    Product Description

    1-oxo Ibuprofen is a degradation product and potential impurity in commercial preparations of ibuprofen.1,2 Ibuprofen (Item No. 70280) is a non-selective, reversible COX inhibitor and non-steroidal anti-inflammatory drug (NSAID).1 Formulations containing ibuprofen are widely used for inflammation, pain, and fever. However, it is considered, among other pharmaceuticals, an environmental contaminant because it cannot be completey biodegraded during the wastewater treatment process.3 Degradation using ultraviolet light, Fe(III), and peroxymonosulfate has been described and results in degradation products, including 1-oxo ibuprofen.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. YongFang, R., Xue, D., Pan, H., et al. Degradation of ibuprofen by a synergistic UV/Fe(III)/Oxone process. Chem. Eng. J. 283, 65-75 (2016).

    2. Vijay Kumar, R., Rao, V.U., Anil Kumar, N., et al. A novel, rapid, and validated stability-indicating UPLC method for the estimation of drotaverine hydrochloride and ibuprofen impurities in oral solid dosage form. Sci. Pharm. 83(4), 567-581 (2015).

    3. Méndez-Arriaga, F., Esplugas, S., and Giménez, J. Degradation of the emerging contaminant ibuprofen in water by photo-Fenton. Water Res. 44(2), 589-595 (2010).