An NSAID and non-selective COX inhibitor
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(±)-Ibuprofen

Item No. 70280

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(±)-α-methyl-4-(2-methylpropyl)-benzeneacetic acid
CAS Number
15687-27-1
Synonyms
  • DL-Ibuprofen
  • NSC 256857
  • U-18753
Molecular Formula
C13H18O2
Formula Weight
206.3
Purity
≥99%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 45 mg/mlDMSO: 50 mg/mlEthanol: 60 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
CC(C)Cc1ccc(cc1)C(C)C(=O)O
InChi Code
InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
InChi Key
HEFNNWSXXWATRW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $17

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    1 g

    $28

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    5 g

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    10 g

    $190

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    Product Description

    (±)-Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and non-selective COX inhibitor (IC50s = 2.6 and 1.3 µM for human recombinant COX-1 and COX-2, respectively).1 In vivo, (±)-ibuprofen inhibits late-phase formalin-induced paw licking in mice (ED50 = 6.1 mg/kg).2 It also inhibits acetic acid-induced writhing in mice (ED50 = 0.47 mg/kg). Formulations containing (±)-ibuprofen have been used in the treatment of fever and mild to severe pain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johnson, J.L., Wimsatt, J., Buckel, S.D., et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch. Biochem. Biophys. 324(1), 26-34 (1995).

    2. Seguin, L., Le Marouille-Girardon, S., and Millan, M.J. Antinociceptive profiles of non-peptidergic neurokinin1 and neurokinin2 receptor antagonists: A comparison to other classes of antinociceptive agent. Pain 61(2), 325-343 (1995).

    Product Citations

    Kundu, D., Franchini, L., Hasdemir, H.S., et al. Distinct interactions of cannabinol and its cytochrome P450-generated metabolites with receptors and sensory neurons. J. Med. Chem. 68(13), 13935-13953 (2025).

    Corwin, C., Nikolopoulou, A., Pan, A.L., et al. Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: Potential novel therapeutic targets. J. Neuroinflammation 15(1), 272 (2018).

    d'Alencon, C.A., Peña, O.A., Wittmann, C., et al. A high-throughput chemically induced inflammation assay in zebrafish. BMC Biol. 8, 151 (2010).