A coenzyme of carboxylase enzymes
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Labeled Version(s)
43148Biotin-d2
Metabolite(s)
34145Biotin (S)-sulfoxide
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Biotin

Item No. 22582

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid
CAS Number
58-85-5
Synonyms
  • D-Biotin
  • NSC 63865
  • Vitamin B7
Molecular Formula
C10H16N2O3S
Formula Weight
244.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
SMILES
O=C(N1)N[C@]([C@]1([H])CS2)([H])[C@@H]2CCCCC(O)=O
InChi Code
InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
InChi Key
YBJHBAHKTGYVGT-ZKWXMUAHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $44

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    5 g

    $143

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    10 g

    $264

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    25 g

    $550

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    Product Description

    Biotin is an essential coenzyme for certain carboxylases. It is used to modify histones and regulate gene transcription.123 Biotin-dependent carboxylases are involved in fatty acid and amino acid synthesis, and play a role in gluconeogenesis.1 In addition, biotin is used in biotechnological applications such as DNA-hybridization, flow cytometry, affinity purification, and identification of protein-protein interactions and post-translational modifications.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tong, L. Structure and function of biotin-dependent carboxylases. Cell Mol. Life Sci. 70(5), 863-891 (2013).

    2. Mock, D.M. Biotin: From Nutrition to Therapeutics. J. Nutr. (2017).

    3. Zempleni, J., Teixeira, D.C., Kuroishi, T., et al. Biotin requirements for DNA damage prevention. Mutat. Res. 733(1-2), 58-60 (2012).

    4. Dundas, C.M., Demonte, D., and Park, S. Streptavidin-biotin technology: Improvements and innovations in chemical and biological applications. Appl. Microbiol. Biotechnol. 97(21), 9343-9353 (2013).