An internal standard for the quantification of biotin
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Unlabeled Version(s)
22582Biotin
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Biotin-d2

Item No. 43148

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic-2,2-d2 acid
Synonyms
  • D-Biotin-d2
  • Vitamin B7<-d2
Molecular Formula
C10H14D2N2O3S
Formula Weight
246.3
Purity
≥99% deuterated forms (d1-d2)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: solubleWater: soluble upon heating
SMILES
OC(C([2H])([2H])CCC[C@H]1[C@]2([H])[C@](NC(N2)=O)([H])CS1)=O
InChi Code
InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1/i4D2
InChi Key
YBJHBAHKTGYVGT-XQDKMORNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    500 µg

    $117

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    1 mg

    $222

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    Product Description

    Biotin-d2 is intended for use as an internal standard for the quantification of biotin (Item No. 22582) by GC- or LC-MS. Biotin is an essential coenzyme for certain carboxylases.1 It is used to modify histones and regulate gene transcription.1,2,3 Biotin-dependent carboxylases are involved in fatty acid and amino acid synthesis and play a role in gluconeogenesis.1 In addition, biotin is used in biotechnological applications such as DNA hybridization, flow cytometry, affinity purification, and identification of protein-protein interactions and post-translational modifications.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tong, L. Structure and function of biotin-dependent carboxylases. Cell Mol. Life Sci. 70(5), 863-891 (2013).

    2. Mock, D.M. Biotin: From Nutrition to Therapeutics. J. Nutr. (2017).

    3. Zempleni, J., Teixeira, D.C., Kuroishi, T., et al. Biotin requirements for DNA damage prevention. Mutat. Res. 733(1-2), 58-60 (2012).

    4. Dundas, C.M., Demonte, D., and Park, S. Streptavidin-biotin technology: Improvements and innovations in chemical and biological applications. Appl. Microbiol. Biotechnol. 97(21), 9343-9353 (2013).