An internal standard for the quantification of ranitidine
Related Products
Unlabeled Version(s)
16939Ranitidine (hydrochloride)
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Ranitidine-d6 (hydrochloride)

Item No. 22583

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(E)-N-(2-(((5-((bis(methyl-d3)amino)methyl)furan-2-yl)methyl)thio)ethyl)-N'-methyl-2-nitroethene-1,1-diamine, monohydrochloride
CAS Number
1185238-09-8
Molecular Formula
C13H16D6N4O3S • HCl
Formula Weight
356.9
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
231, 326 nm
SMILES
CN/C(NCCSCC1=CC=C(CN(C([2H])([2H])[2H])C([2H])([2H])[2H])O1)=C\[N+]([O-])=O.Cl
InChi Code
InChI=1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9+;/i2D3,3D3;
InChi Key
GGWBHVILAJZWKJ-DICWLCDHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $131

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    1 mg

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    Product Description

    Ranitidine-d6 is intended for use as an internal standard for the quantification of ranitidine (Item No. 16939) by GC- or LC-MS. Ranitidine is a histamine H2 receptor antagonist.1 It reverses histamine-induced relaxation of isolated rat uterine horn (pA2 = 6.9) as well as histamine-induced increases in contraction frequency in isolated guinea pig right atrium (pA2 = 7.2). Ranitidine (0.03-3 mg/kg, i.v.) inhibits histamine-and pentagastrin-induced gastric acid secretion in a dose-dependent manner in anesthetized rats. Formulations containing ranitidine have been used in the treatment and prevention of heartburn and gastroesophageal reflux disease (GERD).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Daly, M.J., Humphray, J.M., and Stables, R. Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine. Br. J. Pharmacol. 72(1), 49-54 (1981).