A macrolide antibiotic
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Tylosin

Item No. 22599

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
1401-69-0
Molecular Formula
C46H77NO17
Formula Weight
916.1
Purity
≥98% (mixture of tylosins)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/ml
λmax
282 nm
SMILES
O=C(/C=C/C(C)=C\[C@H](CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC)[C@@H](CC)O2)[C@H](C)CC(CC=O)[C@H](O[C@]3([H])O[C@H](C)[C@@H](O[C@@]4([H])C[C@@](C)(O)[C@@H](O)[C@H](C)O4)[C@H](N(C)C)[C@H]3O)[C@@H](C)[C@H](O)CC2=O
InChi Code
InChI=1S/C46H77NO17/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3/b15-14+,23-18-/t24-,25+,26-,27-,28+,29?,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-/m1/s1
InChi Key
WBPYTXDJUQJLPQ-ZDRCPHIOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Tylosin is a macrolide antibiotic produced by S. fradiae that has bacteriostatic activity against Gram-positive bacteria.1 It is a mixture of tylosin A, B, C, and D, with tylosin A contributing 80% of its bacteriostatic activity. Tylosin has MIC values of 9.6, 16.4, 0.1, 1, and 0.5 μg/ml for F. necrophorum, A. pyogenes, M. gallisepticum, S. aureus, and S. uberis, respectively.2,3,4 Formulations containing tylosin have been used for the prevention of liver abscesses in cattle.3 Tylosin is an environmental contaminant because it is not fully metabolized by treated livestock and enters the environment through manure-based fertilizers.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Arsic, B., Barber, J., Čikoš, A., et al. 16-membered macrolide antibiotics: A review. Int. J. Antimicrob. Agents 30238-30280 (2017).

    2. Bonnier, M., Doré, C., Amédéo, J., et al. In vitro activity of tylosin and tilmicosin against cocci isolated from bovine mastitis. Revue Méd. Vét. 157(10), 486-489 (2006).

    3. Nagaraja, T.G., and Chengappa, M.M. Liver abscesses in feedlot cattle: A review. J. Anim. Sci. 76(1), 287-298 (1998).

    4. Jordan, F.T., and Knight, D. The minimum inhibitory concentration of kitasamycin, tylosin and tiamulin for Mycoplasma gallisepticum and their protective effect on infected chicks. Avian Pathol. 13(2), 151-162 (1984).

    5. Washington, M.T., Moorman, T.B., Soupir, M.L., et al. Monitoring tylosin and sulfamethazine in a tile-drained agricultural watershed using polar organic chemical integrative sampler (POCIS). Sci. Total. Environ. 612, 358-367 (2017).