A 5-HT1A receptor agonist
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Isomer(s)
295167-hydroxy DPAT (hydrobromide)
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8-hydroxy DPAT (hydrobromide)

Item No. 22608

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-(dipropylamino)-5,6,7,8-tetrahydro-1-naphthalenol, monohydrobromide
CAS Number
76135-31-4
Synonyms
  • 8-OH-DPAT
Molecular Formula
C16H25NO • HBr
Formula Weight
328.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml
SMILES
OC1=C2C(CCC(N(CCC)CCC)C2)=CC=C1.Br
InChi Code
InChI=1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H
InChi Key
BATPBOZTBNNDLN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $81

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    25 mg

    $185

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    Product Description

    8-Hydroxy DPAT (8-OH-DPAT) is an agonist of serotonin (5-HT) receptor subtype 5-HT1A (EC50 = 12 nM in rat hippocampal membranes).1 It mimics the effect of serotonin (Item No. 14332) on reducing excitatory post-synaptic potentials (EPSPs) in the entorhinal cortex layers II and III when used at concentrations of 10 and 50 µM.2 In rhesus monkeys, it enhances the behavioral effects of Δ9-tetrahydrocannabinol (Δ9-THC; Item Nos. 12068 | ISO60157) in a discriminant stimulus-shock test when administered at a dose of 0.178 mg/kg.3 In mice, 8-OH-DPAT reduces the number of attack bites when administered directly to the dorsal raphe nucleus in a baclofen-induced model of aggressiveness and impairs contextual fear when administered prior to training at a dose of 0.5 mg/kg.4,5 It also reduces the incidence of apnea and improves respiratory regularity in a methyl-CpG-binding protein 2-deficient mouse model of Rett syndrome when administered at a dose of 50 µg/kg.6 In a rat model of diabetes, 8-OH-DPAT enhances bradycardia in response to vagal electrical stimulation.7

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meller, E., Li, H., Carr, K.D., et al. 5-hydroxytryptamine1A receptor-stimulated [35S]GTPγS binding in rat brain: Absence of regional differences in coupling efficiency. J. Pharmacol. Exp. Ther. 292(2), 684-691 (2000).

    2. Schmitz, D.A., Gloveli, T., Empson, R.M., et al. Serotonin reduces synaptic excitation in the superficial medial entorhinal cortex of the rat via a presynaptic mechanism. J. Physiol. 508(Pt 1), 119-129 (1998).

    3. McMahon, L.R. Enhanced discriminative stimulus effects of Δ9-THC in the presence of cannabidiol and 8-OH-DPAT in rhesus monkeys. Drug Alcohol Depend. 165, 87-93 (2016).

    4. Takahashi, A., Shimamoto, A., Boyson, C.O., et al. GABAB receptor modulation of serotonin neurons in the dorsal raphé nucleus and escalation of aggression in mice. J. Neurosci. 30(35), 11771-11780 (2010).

    5. Stiedl, O., Misane, I., Spiess, J., et al. Involvement of the 5-HT1A receptors in classical fear conditioning in C57BL/6J mice. J. Neurosci. 20922), 8515-8527 (2000).

    6. Abdala, A.P.L., Dutschmann, M., Bissonnette, J.M., et al. Correction of respiratory disorders in a mouse model of Rett syndrome. Proc. Natl. Acad. Sci. USA 107(42), 18208-18213 (2010).

    7. Restrepo, B., Martín, M.L., San Román, L., et al. Peripheral 5-HT1A and 5-HT7 serotonergic receptors modulate parasympathetic neurotransmission in long-term diabetic rats. Exp. Diabetes Res. 686734 (2010).