A fungal metabolite with antioxidant and neuroprotective activities
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Orsellinic Acid

Item No. 22708

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-dihydroxy-6-methyl-benzoic acid
CAS Number
480-64-8
Synonyms
  • o-Orsellinic Acid
  • ortho-Orsellinic Acid
Molecular Formula
C8H8O4
Formula Weight
168.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 0.25 mg/ml
λmax
216, 262, 300 nm
SMILES
CC1=C(C(O)=O)C(O)=CC(O)=C1
InChi Code
InChI=1S/C8H8O4/c1-4-2-5(9)3-6(10)7(4)8(11)12/h2-3,9-10H,1H3,(H,11,12)
InChi Key
AMKYESDOVDKZKV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $63

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    50 mg

    $248

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    100 mg

    $371

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    250 mg

    $696

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    Product Description

    Orsellinic acid is a fungal metabolite and benzoic acid derivative with antioxidant and neuroprotective activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals with an IC50 value of 5 mM.1 Orsellinic acid (1 μg/ml) prevents PARP cleavage induced by platelet-activating factor (PAF) in PC12-AC cells and PAF-induced cytotoxicity in PAF receptor null (Pafr-/-) mouse cerebellar granule cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lopes, T.I.B., Coelho, R.H., Toshida, N.C., et al. Radical-scavenging activity of orsellinates. Chem. Pharm. Bull. (Tokyo) 56(11), 1551-1554 (2008).

    2. Ryan, S.D., Harris, C.S., Mo, F., et al. Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid. J. Neurochem. 103(1), 88-97 (2007).