A ribonucleoside with broad-spectrum antiviral activity
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2'-C-Methylcytidine

Item No. 22887

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2'-C-methyl-cytidine
CAS Number
20724-73-6
Synonyms
  • 2CMC
Molecular Formula
C10H15N3O5
Formula Weight
257.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
275 nm
SMILES
O=C(N=C(N)C=C1)N1[C@H]2[C@](C)(O)[C@H](O)[C@@H](CO)O2
InChi Code
InChI=1S/C10H15N3O5/c1-10(17)7(15)5(4-14)18-8(10)13-3-2-6(11)12-9(13)16/h2-3,5,7-8,14-15,17H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,10-/m1/s1
InChi Key
PPUDLEUZKVJXSZ-VPCXQMTMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    2'-C-Methylcytidine (2CMC) is a ribonucleoside with broad-spectrum antiviral activity.1 It reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses with EC50 values of 95, 26, 80, and 75 μM, respectively. 2CMC inhibits hepatitis C virus (HCV) replication (EC50 = 2.2 μM in a replicon assay) and protects MDBK cells from infection with bovine virus diarrhea virus (BVDV; EC50 = 2.2 μM) and human coronavirus (HCoV; EC50 = 90 μM). It also reduces infectious virus yield in BHK-21 cells infected with foot-and-mouth disease virus (FMDV; EC50 = 6.4 μM) and swine vesicular disease virus (SVDV; EC50 = 45.2 μM).2 In vivo, 2CMC reduces viral shedding to undetectable levels in a mouse model of persistent norovirus infection.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Benzaria, S., Bardiot, D., Bouisset, T., et al. 2′-C-Methyl branched pyrimidine ribonucleoside analogues: Potent inhibitors of RNA virus replication. Antivir. Chem. Chemother. 18(4), 225-242 (2007).

    2. Goris, N., De Palma, A., Toussaint, J.F., et al. 2'-C-methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus. Antiviral Res. 73(3), 161-168 (2007).

    3. Rocha-Pereira, J., Van Dycke, J., and Neyts, J. Treatment with a nucleoside polymerase inhibitor reduces shedding of murine norovirus in stool to undetectable levels without emergence of drug-resistant variants. Antimicrob. Agents Chemother. 60(3), 1907-1911 (2015).