A metabolite of serotonin
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Labeled Version(s)
371995-hydroxy Indole-3-acetic Acid-d6
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5-hydroxy Indole-3-acetic Acid

Item No. 22889

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-hydroxy-1H-indole-3-acetic acid
CAS Number
54-16-0
Synonyms
  • 5-HIAA
  • 5-Hydroxyindoleacetic Acid
  • 5-hydroxy IAA
  • NSC 90432
Molecular Formula
C10H9NO3
Formula Weight
191.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 0.1 mg/ml
SMILES
OC(CC1=CNC2=CC=C(O)C=C21)=O
InChi Code
InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)
InChi Key
DUUGKQCEGZLZNO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $36

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    250 mg

    $84

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    500 mg

    $159

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    1 g

    $300

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    Cayman Chemical
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    Product Description

    5-hydroxy Indole-3-acetic acid (5-HIAA) is a metabolite of the monoamine neurotransmitter serotonin (5-HT; Item No. 14332).1 It is formed from serotonin via a 5-hydroxy indole-3-acetaldehyde intermediate by aldehyde dehydrogenase. 5-HIAA has been used as a biomarker for the detection of neuroendocrine tumors. Brain levels of 5-HIAA are decreased in patients with severe Alzheimer’s disease.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Corcuff, J.-B., Chardon, L., El Hajji Ridah, I., et al. Urinary sampling for 5HIAA and metanephrines determination: Revisiting the recommendations. Endocr. Connect. 6(6), R87-R98 (2017).

    2. Vermeiren , Y., Van Dam, D., Aerts, T., et al. Monoaminergic neurotransmitter alterations in postmortem brain regions of depressed and aggressive patients with Alzheimer’s disease. Neurobiol. Aging 35(12), 2691-2700 (2014).