An internal standard for the quantification of 5-hydroxy indole-3-acetic acid
Related Products
Unlabeled Version(s)
228895-hydroxy Indole-3-acetic Acid
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5-hydroxy Indole-3-acetic Acid-d6

Item No. 37199

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(5-hydroxy-1H-indol-3-yl-2,4,6,7-d4)acetic-2,2-d2 acid
CAS Number
2748469-82-9
Synonyms
  • 5-HIAA-d6
  • 5-Hydroxyindoleacetic Acid-d6
  • 5-hydroxy IAA-d6
Molecular Formula
C10H3D6NO3
Formula Weight
197.2
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthyl Acetate: SolubleMethanol: Soluble
SMILES
OC(C([2H])([2H])C(C1=C2[2H])=C([2H])NC1=C([2H])C([2H])=C2O)=O
InChi Code
InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)/i1D,2D,3D2,4D,5D
InChi Key
DUUGKQCEGZLZNO-AWRNDGDOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    500 µg

    $70

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    1 mg

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    5 mg

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    Product Description

    5-hydroxy Indole-3-acetic acid-d6 (5-HIAA-d6) is intended for use as an internal standard for the quantification of 5-HIAA (Item No. 22889) by GC- or LC-MS. 5-HIAA is a metabolite of the monoamine neurotransmitter serotonin (5-HT; Item No. 14332).1 It is formed from serotonin via a 5-hydroxy indole-3-acetaldehyde intermediate by aldehyde dehydrogenase. 5-HIAA has been used as a biomarker for the detection of neuroendocrine tumors. Brain levels of 5-HIAA are decreased in patients with severe Alzheimer’s disease.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Corcuff, J.-B., Chardon, L., El Hajji Ridah, I., et al. Urinary sampling for 5HIAA and metanephrines determination: Revisiting the recommendations. Endocr. Connect. 6(6), R87-R98 (2017).

    2. Vermeiren , Y., Van Dam, D., Aerts, T., et al. Monoaminergic neurotransmitter alterations in postmortem brain regions of depressed and aggressive patients with Alzheimer’s disease. Neurobiol. Aging 35(12), 2691-2700 (2014).