A fluoroquinolone antibiotic
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Ofloxacin

Item No. 22891

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
CAS Number
82419-36-1
Synonyms
  • DL-8280
  • WP0405
Molecular Formula
C18H20FN3O4
Formula Weight
361.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlDMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml
SMILES
FC1=CC2=C3C(OCC(C)N3C=C(C(O)=O)C2=O)=C1N4CCN(C)CC4
InChi Code
InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
InChi Key
GSDSWSVVBLHKDQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Ofloxacin is a broad-spectrum fluoroquinolone antibiotic that prevents supercoiling of bacterial chromosomes by DNA gyrase.1,2 It is active against Gram-positive and Gram-negative bacteria with MIC90s ranging from 0.39 to 3.13 μg/ml for clinical isolates of S. aureus, S. epidermidis, S. pyogenes, and S. faecalis and ≤0.78 μg/ml for N. gonorrhoeae and various species of Enterobacteriaceae. Ofloxacin is active in vivo, with ED50 values ranging from 0.7 to 75.1 mg/kg in infected mice. Formulations containing ofloxacin have been used to treat urinary tract infections, gonorrhea, prostatitis, and gastroenteritis.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sato, K., Matsuura, Y., Inoue, M., et al. In vitro and in vivo activity of DL-8280, a new oxazine derivative. Antimicrob. Agents and Chemother. 22(4), 548-553 (1982).

    2. Smith, J.T. The mode of action of 4-quinolones and possible mechanisms of resistance. J. Antimicrob. Chemother. 18 (Suppl. D), 21-29 (1986).

    3. Hooper, D.C., and Wolfson, J.S. The fluoroquinolones: pharmacology, clinical uses, and toxicities in humans. Antimicrob. Agents Chemother. 28(5), 716-721 (1985).