An internal standard for the quantification of ofloxacin
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Unlabeled Version(s)
22891Ofloxacin
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Ofloxacin-d8 (hydrochloride)

Item No. 33466

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl-2,2,3,3,5,5,6,6-d8)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, monohydrochloride
CAS Number
2930288-81-4
Molecular Formula
C18H12D8FN3O4 • HCl
Formula Weight
405.9
Purity
≥99% deuterated forms (d1-d8)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
FC1=CC2=C3C(OCC(C)N3C=C(C(O)=O)C2=O)=C1N4C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C4([2H])[2H].Cl
InChi Code
InChI=1S/C18H20FN3O4.ClH/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21;/h7-8,10H,3-6,9H2,1-2H3,(H,24,25);1H/i3D2,4D2,5D2,6D2;
InChi Key
CAOOISJXWZMLBN-JCYLEXHWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Ofloxacin-d8 is intended for use as an internal standard for the quantification of ofloxacin (Item No. 22891) by GC- or LC-MS. Ofloxacin is a broad-spectrum fluoroquinolone antibiotic that prevents supercoiling of bacterial chromosomes by DNA gyrase.1,2 It is active against Gram-positive and Gram-negative bacteria with MIC90s ranging from 0.39 to 3.13 μg/ml for clinical isolates of S. aureus, S. epidermidis, S. pyogenes, and S. faecalis and ≤0.78 μg/ml for N. gonorrhoeae and various species of Enterobacteriaceae. Ofloxacin is active in vivo, with ED50 values ranging from 0.7 to 75.1 mg/kg in infected mice. Formulations containing ofloxacin have been used to treat urinary tract infections, gonorrhea, prostatitis, and gastroenteritis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sato, K., Matsuura, Y., Inoue, M., et al. In vitro and in vivo activity of DL-8280, a new oxazine derivative. Antimicrob. Agents and Chemother. 22(4), 548-553 (1982).

    2. Smith, J.T. The mode of action of 4-quinolones and possible mechanisms of resistance. J. Antimicrob. Chemother. 18 (Suppl. D), 21-29 (1986).