An alkaloid with diverse biological activities
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Matrine

Item No. 22901

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(7aS,13aR,13bR,13cS)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
CAS Number
519-02-8
Synonyms
  • NSC 146051
  • NSC 318810
Molecular Formula
C15H24N2O
Formula Weight
248.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 33.3 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C1CCC[C@@]2([H])N1C[C@@]3([H])[C@@]4([H])[C@]2([H])CCCN4CCC3
InChi Code
InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1
InChi Key
ZSBXGIUJOOQZMP-JLNYLFASSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

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    Product Description

    Matrine is an alkaloid found in S. flavescens roots that has diverse biological activities. It inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages in vitro.1 In mice, administration of matrine inhibits the development of LPS-induced hepatitis in a dose-dependent manner.2 Matrine reduces production of the hepatitis B surface antigen (HBsAG) and serum antigen (HBeAG) with IC50 values of 0.75 and 3.35 mg/mL, respectively, in vitro and inhibits viral replication in a duck model of hepatitis B.3 In vitro, matrine inhibits angiotension II-induced hyperplastic growth of cardiac fibroblasts in a dose-dependent manner.4 Matrine also inhibits proliferation of melanoma, breast, and colon cancer cells with IC50s ranging from 0.769-2.758 mg/ml.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hu, Z.-L., Zhang, J.-P., Qian, D.-H., et al. Effects of matrine on mouse splenocyte proliferation and release of interleukin-1 and -6 from peritoneal macrophages in vitro. Zhongguo Yao Li Xue Bao. 17(3), 259-261 (1996).

    2. Hu, Z.-L., Zhang, J.-P., Yu, X.-B., et al. Effect of matrine on lipopolysaccharides/D-galactosamine-induced hepatitis and tumor necrosis factor release from macrophages in vitro. Zhongguo Yao Li Xue Bao. 17(4), 351-353 (1996).

    3. Li, C.-Q., Zhu, Y.-T., Zhang, F.-X., et al. Anti-HBV effect of liposome-encapsulated matrine in vitro and in vivo. World J. Gastroenterol. 11(3), 426-428 (2005).

    4. Li, Y., Wang, B., Zhou, C., et al. Matrine induces apoptosis in angiotensin II-stimulated hyperplasia of cardiac fibroblasts: Effects on Bcl-2/Bax expression and caspase-3 activation. Basic Clin. Pharmacol. Toxicol. 101(1), 1-8 (2007).

    5. Jin, H., Sun, Y., Wang, S., et al. Matrine activates PTEN to induce growth inhibition and apoptosis in V600EBRAF harboring melanoma cells. Int. J. Mol. Sci. 14(8), 16040-16057 (2013).