A quinolizidine alkaloid with diverse biological activities
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Isomer(s)
22901Matrine
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Sophoradin

Item No. 33087

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(7aR,13aR,13bR,13cS)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one
CAS Number
6882-68-4
Synonyms
  • (−)-Sophoridine
Molecular Formula
C15H24N2O
Formula Weight
248.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 10 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C1N2[C@@](CCC1)([H])[C@]3([H])[C@]4([H])[C@@](CCCN4CCC3)([H])C2
InChi Code
InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12-,13-,15+/m1/s1
InChi Key
ZSBXGIUJOOQZMP-BHPKHCPMSA-N
Origin
Plant/Sophora alopecuroides
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

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    500 mg

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    1 g

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    Product Description

    Sophoradin is a quinolizidine alkaloid that has been found in S. alopecuroides and has diverse biological activities.1,2,3 It reduces viral titers in primary neonatal rat cardiomyocytes infected with coxsackievirus B3 (CVB3) when used at concentrations of 1 and 5 µg/ml.2 Sophoradin inhibits the growth of, and induces apoptosis in, SW480 colorectal cancer cells, as well as reduces tumor growth in an SW480 mouse xenograft model.1 It reduces increases in TNF-α, IL-8, and prostaglandin E2 (PGE2; Item No. 14010) levels in the inflammatory exudate in a mouse model of carrageenan-induced paw edema when administered at doses of 12.15 and 48.6 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liang, L., Wang, X.-Y., Zhang, X.-H., et al. Sophoridine exerts an anti-colorectal carcinoma effect through apoptosis induction in vitro and in vivo. Life Sci. 91(25-26), 1295-1303 (2012).

    2. Zhang, Y., Zhu, H., Ye, G., et al. Antiviral effects of sophoridine against coxsackievirus B3 and its pharmacokinetics in rats. Life Sci. 78(17), 1998-2005 (2006).

    3. Huang, X., Li, B., and Shen, L. Studies on the anti-inflammatory effect and its mechanisms of sophoridine. J. Anal. Methods Chem. 502626 (2014).