An activator of glucokinase
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LY2608204

Item No. 22914

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,2S)-2-cyclohexyl-1-[4-(cyclopropylsulfonyl)phenyl]-N-[5-[[2-(1-pyrrolidinyl)ethyl]thio]-2-thiazolyl]-cyclopropanecarboxamide
CAS Number
1234703-40-2
Molecular Formula
C28H37N3O3S3
Formula Weight
559.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMF:PBS(pH7.2) (1:2): 0.33 mg/mlDMSO: 25 mg/ml
λmax
232, 285 nm
SMILES
O=S(C1=CC=C([C@]2(C[C@H]2C3CCCCC3)C(NC4=NC=C(SCCN5CCCC5)S4)=O)C=C1)(C6CC6)=O
InChi Code
InChI=1S/C28H37N3O3S3/c32-26(30-27-29-19-25(36-27)35-17-16-31-14-4-5-15-31)28(18-24(28)20-6-2-1-3-7-20)21-8-10-22(11-9-21)37(33,34)23-12-13-23/h8-11,19-20,23-24H,1-7,12-18H2,(H,29,30,32)/t24-,28-/m0/s1
InChi Key
QIIVJLHCZUTGSD-CUBQBAPOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $48

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    5 mg

    $218

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    10 mg

    $388

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    25 mg

    $853

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    LY2608204 is an activator of glucokinase (GK; EC50 = 42 nM).1 It stimulates glucose metabolism in INS-1E rat insulinoma cells (mean EC50 = 579 nM). LY2608204 (30 mg/kg) decreases plasma glucose levels in a dose-dependent manner in fasted rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bueno Melendo, A.B., and Agejas-Chicharro, F.J. Cyclopropyl compounds. (2010).