An antiviral guanosine analog
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Pro-drug Form(s)
23834Famciclovir
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Penciclovir

Item No. 22918

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one
CAS Number
39809-25-1
Synonyms
  • BRL 39123
Molecular Formula
C10H15N5O3
Formula Weight
253.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.33 mg/ml
λmax
256 nm
SMILES
NC(NC1=C2N=CN1CCC(CO)CO)=NC2=O
InChi Code
InChI=1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)
InChi Key
JNTOCHDNEULJHD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

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    Cayman Chemical
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    Product Description

    Penciclovir is a guanosine analog with antiviral activity.1 It has activity against multiple laboratory and clinical isolate strains of herpes simplex virus 1 (HSV-1), HSV-2, and varicella zoster virus (VZV) in a plaque reduction assay (IC50s = 0.4-3.1 μg/ml). Penciclovir inhibits HSV-1 and HSV-2 replication (IC99s = 0.4 and 0.7 μg/ml, respectively) and DNA synthesis (IC50 = 0.04 μg/ml) in MRC-5 cells.1,2 In vivo, topical and systemic administration of penciclovir reduces the severity of skin lesions caused by HSV-1 in guinea pigs and mice.3 It also prevents development of HSV-2-induced genital lesions in guinea pigs infected intravaginally.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boyd, M.R., Bacon, T.H., Sutton, D., et al. Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxy-methylbut-1-yl)guanine (BRL 39123) in cell culture. Antimicrob. Agents and Chemother. 31(8), 1238-1242 (1987).

    2. Hodge, R.A., and Perkins, R.M. Mode of action of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (BRL 39123) against herpes simplex virus in MRC-5 cells. Antimicrob. Agents and Chemother. 33(2), 223-229 (1989).

    3. Boyd, M.R., Bacon, T.H., and Sutton, D. Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxymethylbut-1-yl) guanine (BRL 39123) in animals. Antimicrob. Agents Chemother. 32(3), 358-363 (1988).