An orally bioavailable prodrug form of penciclovir
Related Products
Active Metabolite(s)
22918Penciclovir
Metabolite(s)
356026-Deoxypenciclovir
Technical Support & Resources

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Famciclovir

Item No. 23834

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-(2-amino-9H-purin-9-yl)ethyl]-1,3-propanediol, 1,3-diacetate
CAS Number
104227-87-4
Synonyms
  • BRL 42810
Molecular Formula
C14H19N5O4
Formula Weight
321.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
223, 311 nm
SMILES
NC1=NC(N(CCC(COC(C)=O)COC(C)=O)C=N2)=C2C=N1
InChi Code
InChI=1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)
InChi Key
GGXKWVWZWMLJEH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $36

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    50 mg

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    100 mg

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    250 mg

    $203

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    Cayman Chemical
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    Product Description

    Famciclovir is an orally bioavailable prodrug form of the antiviral guanosine analog penciclovir (Item No. 22918).1 Famciclovir is rapidly deacetylated and oxidized in vivo to form penciclovir, which is active against clinical isolates of herpes simplex virus 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV) in a plaque reduction assay with IC50 values of 1.6, 6, and 12 μM, respectively. Both famciclovir and the product of its deacetylation, 6-deoxypenciclovir, are oxidized in vitro by human, guinea pig, and rat liver aldehyde oxidase, with 6-deoxypenciclovir being converted to penciclovir.2 Peak plasma concentrations of penciclovir (mean 3.5 μg/ml) are reached 0.5 hours after oral administration of famciclovir (40 mg/kg) in rats.3 Famciclovir (25 mg/kg) has a longer half-life in dogs, with peak concentrations of penciclovir (mean 4.4 μg/ml) in plasma occurring after 3 hours.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hodge, R.A.V. Famciclovir and penciclovir. The mode of action of famciclovir including its conversion to penciclovir. Antivir. Chem. Chemother. 4(2), 67-84 (1993).

    2. Rashidi, M.R., Smith, J.A., Clarke, S.E., et al. In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver. Drug Metab. Dispos. 25(7), 805-813 (1997).

    3. Filer, C.W., Ramji, J.V., Allen, G.D., et al. Metabolic and pharmacokinetic studies following oral administration of famciclovir to the rat and dog. Xenobiotica. 25(5), 477-490 (1995).