A 5-HT1D antagonist
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LY310762

Item No. 22938

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-one, monohydrochloride
CAS Number
192927-92-7
Molecular Formula
C24H27FN2O2 • HCl
Formula Weight
430.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.14 mg/mlEthanol: 0.5 mg/ml
λmax
249, 273 nm
SMILES
FC1=CC=C(C(C2CCN(CCN(C3=C(C=CC=C3)C4(C)C)C4=O)CC2)=O)C=C1.Cl
InChi Code
InChI=1S/C24H27FN2O2.ClH/c1-24(2)20-5-3-4-6-21(20)27(23(24)29)16-15-26-13-11-18(12-14-26)22(28)17-7-9-19(25)10-8-17;/h3-10,18H,11-16H2,1-2H3;1H
InChi Key
BOCLFQZPFYNVFD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $80

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    10 mg

    $149

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    25 mg

    $312

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    Product Description

    LY310762 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT1D (Ki = 249 nM for guinea pig receptors).1 It is selective for 5-HT1D over the 5-HT1B receptor, where it inhibits binding of radiolabeled citalopram by only 32% when used at a concentration of 1,000 nM. LY310762 potentiates 5-HT (Item No. 14332) release stimulated by potassium in guinea pig cortex (EC50 = 31 nM). It also reverses vasodilation induced by 5-HT in rat kidney perfused by phenylephrine (Item Nos. 17205 | 18619) when administered at a dose of 1 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pullar, I.A., Boot, J.R., Broadmore, R.J., et al. The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig. Eur. J. Pharmacol. 493(1-3), 85-93 (2004).

    2. García-Pedraza, J.Á., García, M., Martín, M.L., et al. Pharmacological evidence that 5-HT1D activation induces renal vasodilation by NO pathway in rats. Clin. Exp. Pharmacol. Physiol. 42(6), 640-647 (2015).