A RARα antagonist
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AR-7

Item No. 22946

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine
CAS Number
80306-38-3
Molecular Formula
C15H12ClNO
Formula Weight
257.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
225, 233, 240, 254, 337 nm
SMILES
ClC1=CC=C2C(OCC(C3=CC=C(C)C=C3)=N2)=C1
InChi Code
InChI=1S/C15H12ClNO/c1-10-2-4-11(5-3-10)14-9-18-15-8-12(16)6-7-13(15)17-14/h2-8H,9H2,1H3
InChi Key
MVOZLTFXYGHZPM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    AR-7 is a retinoic acid receptor α (RARα) antagonist.1 In mouse fibroblasts, AR-7 (20 μM) increases chaperone-mediated autophagy in an RARα-dependent manner, increases LAMP-2A expression, and inhibits paraquat-induced decreases in cell viability. AR-7 is also selectively cytotoxic to HepG2 cells grown under hypoxic over normoxic conditions (IC50s = 10 and >1,000 μM, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Anguiano, J., Garner, T.P., Mahalingam, M., et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat. Chem. Biol. 9(6), 374-382 (2013).

    2. Das, B.C., Madhukumar, A.V., Anguiano, J., et al. Design, synthesis and biological evaluation of 2H-benzo[b][1,4] oxazine derivatives as hypoxia targeted compounds for cancer therapeutics. Bioorg. Med. Chem. Lett. 19(15), 4204-4206 (2009).