An agonist of GPR119
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APD597

Item No. 22950

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[5-methoxy-6-[[2-methyl-6-(methylsulfonyl)-3-pyridinyl]amino]-4-pyrimidinyl]oxy]-1-piperidinecarboxylic acid, 1-methylethyl ester
CAS Number
897732-93-3
Synonyms
  • JNJ-38431055
Molecular Formula
C21H29N5O6S
Formula Weight
479.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25mg/mLDMSO: 25mg/mLEthanol: 50mg/mLEthanol:PBS (pH 7.2) (1:3): 0.25mg/mL
λmax
311 nm
SMILES
CC(OC(N1CCC(OC2=C(OC)C(NC3=C(C)N=C(S(C)(=O)=O)C=C3)=NC=N2)CC1)=O)C
InChi Code
InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
InChi Key
WPDCHTSXOPUOII-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

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    25 mg

    $402

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    50 mg

    $702

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    APD597 is an orally bioavailable agonist of GPR119 that has EC50 values of 46 and 421 nM for the human and rat receptors, respectively, in a homologous time-resolved fluorescence (HTRF) assay.1 It increases insulin secretion stimulated by a high, but not low, concentration of glucose in isolated mouse pancreatic β-cells and in isolated human islets.2 APD597 (20 mg/kg) increases levels of glucagon-like peptide-1 (GLP-1; Item No. 24460) induced by glucose in mice. It also decreases blood glucose levels in an oral glucose tolerance test in mice when administered at doses of 1 and 10 mg/kg and in Zucker diabetic rats at a dose of 3 mg/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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