AGE-BSA produced by incubating BSA with glucose
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AGE-BSA (Glucose modified)

Item No. 22968

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Advanced Glycation End Product - Bovine Serum Albumin
  • Glucose AGE-BSA
Source
Albumin isolated from bovine plasma and modified with glucose
MW
69.3 kDa
Formulation (Request formulation change)
Lyophilized from a solution in PBS, pH 7.4, at 10 mg per vial. Reconstitution with 0.2 ml of water will yield 50 mg/ml solution in 1X PBS
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

    $285

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Advanced glycation end products (AGEs) are formed from the nonenzymatic reaction of amino groups with reducing sugars.1,2,3 AGEs have been implicated in diseases, such as diabetes mellitus, non-diabetic nephropathy, macrovascular disease, Alzheimer’s disease, cataract, and ageing.1,2,3 AGE-BSA (Glucose modified) has been used as a standard for AGEs in ELISAs and to determine the effects of AGEs on cells in culture.4,5,6 AGE-BSA (Glucose modified) was produced by incubating BSA with glucose, followed by extensive dialysis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Singh, R., Barden, A., Mori, T., et al. Advanced glycation end-products: A review. Diabetologia 44(2), 129-146 (2001).

    2. Giacco, F., and Brownlee, M. Oxidative stress and diabetic complications. Circ. Res. 107(9), 1058-1070 (2010).

    3. Vistoli, G., De Maddis, D., Cipak, A., et al. Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): An overview of their mechanisms of formation. Free Radic. Res. 47(Suppl 1), 3-27 (2013).

    4. Cai, W., Gao, Q.d., Zhu, L., et al. Oxidative stress-inducing carbonyl compounds from common foods: Novel mediators of cellular dysfunction. Mol. Med. 8(7), 337-346 (2002).

    5. Dedert, C., Mishra, V., Aggarwal, G., et al. Progranulin preserves autophagy flux and mitochondrial function in rat cortical neurons under high glucose stress. Front. Cell. Neurosci. 16, 874258 (2022).

    6. Xia, C., Zhang, J., Chen, H., et al. ShenQi ShenKang granule alleviates chronic kidney disease by inhibiting the PI3K/AKT/mTOR pathway and restoring autophagy flux and mitochondrial integrity. Drug Des. Devel. Ther. 19, 3925-3947 (2025).

    Product Citations

    Baek, C.H., Kim, H., Moon, S.Y., et al. AKT activation triggers Rab14-mediated ADAM10 translocation to the cell surface in human aortic endothelial cells. Sci. Rep. 15(1), 7448 (2025).

    Xia, C., Zhang, J., Chen, H., et al. ShenQi ShenKang granule alleviates chronic kidney disease by inhibiting the PI3K/AKT/mTOR pathway and restoring autophagy flux and mitochondrial integrity. Drug Des. Devel. Ther. 19, 3925-3947 (2025).

    Dedert, C., Mishra, V., Aggarwal, G., et al. Progranulin preserves autophagy flux and mitochondrial function in rat cortical neurons under high glucose stress. Front. Cell. Neurosci. 16, 874258 (2022).

    Yang, X., Liu, C.-J., Wang, Z.-Z., et al. Effects of advanced glycation end products on osteocytes mechanosensitivity. Biochem. Biophys. Res. Commun. 568, 151-157 (2021).