AGE-BSA (Glycoaldehyde modified) produced by incubating BSA with glycolaldehyde
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AGE-BSA (Glycoaldehyde modified)

Item No. 22969

Technical Information
Synonyms
  • Glycolaldehyde-Bovine Serum Albumin
  • Glycolaldehyde-BSA
Source
Albumin isolated from bovine plasma and modified with glycolaldehyde
MW
69.3 kDa
Lyophilized from a solution in PBS, pH 7.4, at 10 mg per vial. Reconstitution with 2 ml of 1X PBS will yield a 5 mg/ml solution
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Advanced glycation end products (AGEs) are formed from the nonenzymatic reaction of amino groups with reducing sugars.1,2,3 AGEs have been implicated in diseases, such as diabetes mellitus, non-diabetic nephropathy, macrovascular disease, Alzheimer’s disease, cataract, and ageing.1,2,3 AGE receptors, such as the receptor for AGE (RAGE), mediate biological responses to AGEs, including endocytic uptake and degradation and induction of cytokines and growth factors.1,2,3 AGE-BSA (Glycoaldehyde modified) was produced by incubating BSA with glycolaldehyde, followed by extensive dialysis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Singh, R., Barden, A., Mori, T., et alAdvanced glycation end-products: A review. Diabetologia 44(2), 129-146 (2001).

    2. Giacco, F., and Brownlee, M. Oxidative stress and diabetic complications. Circ. Res. 107(9), 1058-1070 (2010).

    3. Vistoli, G., De Maddis, D., Cipak, A., et alAdvanced glycoxidation and lipoxidation end products (AGEs and ALEs): An overview of their mechanisms of formation. Free Radic. Res. 47(Suppl 1), 3-27 (2013).