Albumin isolated from bovine plasma and modified with glyoxal
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AGE-BSA (Glyoxal modified)

Item No. 22970

Technical Information
Synonyms
  • Glyoxal BSA
  • Glyoxal-Bovine Serum Albumin
  • GO-Bovine Serum Albumin
Source
Albumin isolated from bovine plasma and modified with glyoxal
MW
69.3 kDa
Lyophilized from a solution in PBS, pH 7.4, at 0.2 mg per vial. Reconstitution in 0.2 ml of water will yield 1 mg/ml solution in 1X PBS
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Advanced glycation end products (AGEs) are formed from the nonenzymatic reaction of amino groups with reducing sugars.1,2,3 AGEs have been implicated in diseases, such as diabetes mellitus, non-diabetic nephropathy, macrovascular disease, Alzheimer’s disease, cataract, and ageing.1,2,3 AGE receptors, such as the receptor for AGE (RAGE), mediate biological responses to AGEs, including endocytic uptake and degradation and induction of cytokines and growth factors.1,2,3 AGE-BSA (glyoxal modified) was produced by incubating BSA with glyoxal, followed by extensive dialysis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Singh, R., Barden, A., Mori, T., et alAdvanced glycation end-products: A review. Diabetologia 44(2), 129-146 (2001).

    2. Giacco, F., and Brownlee, M. Oxidative stress and diabetic complications. Circ. Res. 107(9), 1058-1070 (2010).

    3. Vistoli, G., De Maddis, D., Cipak, A., et alAdvanced glycoxidation and lipoxidation end products (AGEs and ALEs): An overview of their mechanisms of formation. Free Radic. Res. 47(Suppl 1), 3-27 (2013).