A reagent used in electron microscopy techniques
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Cacodylic Acid (sodium salt hydrate)

Item No. 22996

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
dimethyl-arsinic acid, monosodium salt, trihydrate
CAS Number
6131-99-3
Molecular Formula
C2H6AsO2 • Na [3H2O]
Formula Weight
214.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 400 mg/mLWater: 100 g/L
SMILES
C[As]([O-])(C)=O.[Na+].O.O.O
InChi Code
InChI=1S/C2H7AsO2.Na.3H2O/c1-3(2,4)5;;;;/h1-2H3,(H,4,5);;3*1H2/q;+1;;;/p-1
InChi Key
RLGWPHBPRCROJO-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

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    Cayman Chemical
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    Product Description

    Cacodylic acid has been widely used in buffers for electron microscopy techniques.1 It has also been used to introduce arsenic into proteins for single-wavelength anomalous diffraction (SAD) phasing in protein crystallography.2 In rats exposed to carcinogens, cacodylic acid increases the likelihood of tumor formation in the bladder, kidney, liver, and thyroid gland at concentrations as low as 50 ppm for the bladder.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Graham, L., and Orenstein, J.M. Processing tissue and cells for transmission electron microscopy in diagnostic pathology and research. Nat. Protoc. 2(10), 2439-2450 (2007).

    2. Liu, X., Zhang, H., Wang, X.J., et al. Get phases from arsenic anomalous scattering: De novo SAD phasing of two protein structures crystallized in cacodylate buffer. PLoS One 6(9), 1-8 (2011).

    3. Yamamoto, S., Konishi, Y., Matsuda, T., et al. Cancer induction by an organic arsenic compound, dimethylarsinic acid (cacodylic acid), in F344/DuCrj rats after pretreatment with five carcinogens. Cancer Res. 55(6), 1271-1276 (1995).