An inhibitor of L-type calcium channels
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Labeled Version(s)
31979Clevidipine-d7
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Clevidipine

Item No. 23025

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3-methyl 5-[(1-oxobutoxy)methyl] ester
CAS Number
167221-71-8
Synonyms
  • rac-Clevidipine
Molecular Formula
C21H23Cl2NO6
Formula Weight
456.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 20 mg/ml
λmax
239, 363 nm
SMILES
CC1=C(C(OC)=O)C(C2=C(Cl)C(Cl)=CC=C2)C(C(OCOC(CCC)=O)=O)=C(C)N1
InChi Code
InChI=1S/C21H23Cl2NO6/c1-5-7-15(25)29-10-30-21(27)17-12(3)24-11(2)16(20(26)28-4)18(17)13-8-6-9-14(22)19(13)23/h6,8-9,18,24H,5,7,10H2,1-4H3
InChi Key
KPBZROQVTHLCDU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    25 mg

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    50 mg

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    100 mg

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    Product Description

    Clevidipine is an inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes).1 It preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively).2 Clevidipine decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats with ED30 values of 316 and 58 nmol/kg, respectively. Formulations containing clevidipine have been used in the treatment of hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yi, X., Vivien, B., and Lynch, C., III Clevidipine blockade of L-type Ca2+ currents: Steady-state and kinetic electrophysiological studies in guinea pig ventricular myocytes. J. Cardiovasc. Pharmacol. 36(5), 592-600 (2000).

    2. Norlander, M., Sjöquist, P.O., Ericsson, H., et al. Pharmacodynamic, pharmacokinetic and clinical effects of clevidipine, an ultrashort-acting calcium antagonist for rapid blood pressure control. Cardiovasc. Drugs Ther. 22(3), 227-250 (2004).