An internal standard for the quantification of clevidipine
Related Products
Unlabeled Version(s)
23025Clevidipine
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Clevidipine-d7

Item No. 31979

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3-methyl 5-[(1-oxobutoxy-d7)methyl] ester
CAS Number
2747918-66-5
Synonyms
  • rac-Clevidipine-d7
Molecular Formula
C21H16Cl2D7NO6
Formula Weight
463.4
Purity
≥99% deuterated forms (d1-d7)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C(C1=C(C)NC(C)=C(C1C2=C(Cl)C(Cl)=CC=C2)C(OCOC(C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)=O)OC
InChi Code
InChI=1S/C21H23Cl2NO6/c1-5-7-15(25)29-10-30-21(27)17-12(3)24-11(2)16(20(26)28-4)18(17)13-8-6-9-14(22)19(13)23/h6,8-9,18,24H,5,7,10H2,1-4H3/i1D3,5D2,7D2
InChi Key
KPBZROQVTHLCDU-ISARVPQGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $363

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    Product Description

    Clevidipine-d7 is intended for use as an internal standard for the quantification of clevidipine (Item No. 23025) by GC- or LC-MS. Clevidipine is an inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes).1 It preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively).2 Clevidipine decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats with ED30 values of 316 and 58 nmol/kg, respectively. Formulations containing clevidipine have been used in the treatment of hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yi, X., Vivien, B., and Lynch, C., III Clevidipine blockade of L-type Ca2+ currents: Steady-state and kinetic electrophysiological studies in guinea pig ventricular myocytes. J. Cardiovasc. Pharmacol. 36(5), 592-600 (2000).

    2. Norlander, M., Sjöquist, P.O., Ericsson, H., et al. Pharmacodynamic, pharmacokinetic and clinical effects of clevidipine, an ultrashort-acting calcium antagonist for rapid blood pressure control. Cardiovasc. Drugs Ther. 22(3), 227-250 (2004).