An FGFR4 inhibitor
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FGF401

Item No. 23029

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-1,8-naphthyridine-1(2H)-carboxamide
CAS Number
1708971-55-4
Synonyms
  • Roblitinib
Molecular Formula
C25H30N8O4
Formula Weight
506.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: 30 mg/mlDMSO: 5 mg/ml
λmax
227, 248, 284 nm
SMILES
CN1CC(N(CC2=CC(CCCN3C(NC4=NC=C(C#N)C(NCCOC)=C4)=O)=C3N=C2C=O)CC1)=O
InChi Code
InChI=1S/C25H30N8O4/c1-31-7-8-32(23(35)15-31)14-18-10-17-4-3-6-33(24(17)29-21(18)16-34)25(36)30-22-11-20(27-5-9-37-2)19(12-26)13-28-22/h10-11,13,16H,3-9,14-15H2,1-2H3,(H2,27,28,30,36)
InChi Key
BHKDKKZMPODMIQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

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    10 mg

    $322

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    25 mg

    $702

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    Cayman Chemical
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    Product Description

    FGF401 is an inhibitor of FGF receptor 4 (FGFR4; IC50 = 1.9 nM).1 It inhibits proliferation of Huh7 carcinoma cells with an IC50 value of 12 nM. FGF401 induces bile acid synthesis in dogs, increasing plasma and fecal levels of bile acids when administered at a dose of 45 mg/kg per day for four weeks.2 It also decreases serum cholesterol when administered at doses ranging from 5 to 45 mg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Buschmann, N., Fairhurst, R.A., Furet, P., et al. Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors. (2015).

    2. Schadt, H.S., Wolf, A., Mahl, J.A., et al. Bile acid sequestration by cholestyramine mitigates FGFR4 inhibition-induced ALT elevation. Toxicol. Sci. 163(1), 265-278 (2018).