Diflubenzuron

Diflubenzuron is a benzoylphenylurea insecticide that inhibits chitin synthesis in insects with an IC₅₀ value of 0.611 nM for ¹⁴C-labeled N-acetyl-D-glucosamine incorporation in the cockroach.^1,2 Specifically, it inhibits chitin synthetase at the egg and larval stages, leading to an inability to exit the egg or exocuticle, respectively.² Diflubenzuron is genotoxic and mutagenic in mice at doses of 0.3, 1, and 3 mg/kg.³ Formulations containing diflubenzuron are used primarily in agricultural applications but are also used to control insects in livestock production.

WARNING This product is not for human or veterinary use.

1. Verloop, A., and Ferrell, C.D. Pesticide Chemistry in the 20^th Century. 37, 237-270 (1977).

2. de Barros, A.L., de Souza, V.V., Navarro, S.D., et al. Genotoxic and mutagenic effects of diflubenzuron, an insect growth regulator, on mice. J. Toxicol. Environ. Health A 76(17), 1003-1006 (2013).

3. Heuckeroth, R.O., Glaser, L., and Gordon, J.I. Heteroatom-substituted fatty acid analogs as substrates for N-myristoyltransferase: An approach for studying both the enzymology and function of protein acylation. Proc. Natl. Acad. Sci. USA 85(23), 8795-9799 (1988).