A PCSK9 inhibitor
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SBC-110736

Item No. 23103

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[[4-(4-methylphenyl)-2-phenyl-1-piperazinyl]carbonyl]phenyl]-acetamide
CAS Number
1629166-02-4
Molecular Formula
C26H27N3O2
Formula Weight
413.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2) (1:4): 0.20 mg/mlDMSO: 10 mg/ml
λmax
253 nm
SMILES
CC1=CC=C(N2CCN(C(C3=CC=C(NC(C)=O)C=C3)=O)C(C4=CC=CC=C4)C2)C=C1
InChi Code
InChI=1S/C26H27N3O2/c1-19-8-14-24(15-9-19)28-16-17-29(25(18-28)21-6-4-3-5-7-21)26(31)22-10-12-23(13-11-22)27-20(2)30/h3-15,25H,16-18H2,1-2H3,(H,27,30)
InChi Key
PILMFSWQYWYOJC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $255

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    25 mg

    $534

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    SBC-110736 is an inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9).1 It increases LDL receptor (LDLR) levels in HepG2 cells expressing PCSK9 when used at a concentration of 400 nM. SBC-110736 (8 mg/kg per day) reduces plasma total cholesterol levels by a mean of 38% in mice fed a high-fat diet. It also reduces plasma LDL cholesterol levels in mice fed a high-fat diet and exhibits an additive effect when administered in combination with atorvastatin (Item No. 10493).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1.  .