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Vorapaxar

Item № 23119
CAS № 618385-01-6
Purity ≥98%
product image
                (CAS 618385-01-6)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $39.00 0.00
     5 mg $166.00 0.00

Pricing updated 2019-05-23. Prices are subject to change without notice.

Description

Vorapaxar is an orally bioavailable competitive antagonist of the proteinase-activated receptor (PAR1; Ki = 8.1 nM), also known as the thrombin receptor.1 It is selective for PAR1 over other PARs, as well as a number of GPCRs, ion channels, and receptors. It inhibits platelet aggregation induced by thrombin (Item No. 13188) and haTRAP (IC50s = 47 and 25 nM, respectively). Vorapaxar (0.1 mg/kg, i.v.) completely inhibits platelet aggregation in cynomolgus monkeys ex vivo. Formulations containing vorapaxar are used in the prevention of thrombotic cardiovascular events.

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Technical Information
Formal Name
N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-carbamic acid, ethyl ester
CAS Number
618385-01-6
Molecular Formula
C29H33FN2O4
Formula Weight
492.6
Purity
≥98%
Formulation
A crystalline solid
λmax
272, 306 nm
SMILES
C[C@@H](OC1=O)[C@]2([H])[C@@]1([H])C[C@@](C[C@H](NC(OCC)=O)CC3)([H])[C@]3([H])[C@@H]2/C=C/C4=CC=C(C5=CC(F)=CC=C5)C=N4
InChI Code
InChI=1S/C29H33FN2O4/c1-3-35-29(34)32-23-10-11-24-20(14-23)15-26-27(17(2)36-28(26)33)25(24)12-9-22-8-7-19(16-31-22)18-5-4-6-21(30)13-18/h4-9,12-13,16-17,20,23-27H,3,10-11,14-15H2,1-2H3,(H,32,34)/b12-9+/t17-,20+,23-,24-,25+,26-,27+/m1/s1
InChI Key
ZBGXUVOIWDMMJE-QHNZEKIYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Chackalamannil, S., Wang, Y., Greenlee, W.J., et al. Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity J. Med. Chem. 51(110), 3061-3064 (2008).

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