An antagonist of CCR9
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Vercirnon

Item No. 23131

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-chloro-2-[(1-oxido-4-pyridinyl)carbonyl]phenyl]-4-(1,1-dimethylethyl)-benzenesulfonamide
CAS Number
698394-73-9
Synonyms
  • CCX282-B
  • GSK1605786
Molecular Formula
C22H21ClN2O4S
Formula Weight
444.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/ml
λmax
226, 313 nm
SMILES
O=C(C(C=C1)=CC=[N]1=O)C(C=C(Cl)C=C2)=C2N[S](=O)(C3=CC=C(C(C)(C)C)C=C3)=O
InChi Code
InChI=1S/C22H21ClN2O4S/c1-22(2,3)16-4-7-18(8-5-16)30(28,29)24-20-9-6-17(23)14-19(20)21(26)15-10-12-25(27)13-11-15/h4-14,24H,1-3H3
InChi Key
JRWROCIMSDXGOZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $90

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    5 mg

    $415

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    Product Description

    Vercirnon is an orally bioavailable antagonist of chemokine receptor 9 (CCR9) with an IC50 value of 5.4 nM for inhibition of CCL25-induced calcium mobilization in Molt-4 cells.1 It is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s = >10 µM for all). It also inhibits CCL25-induced Molt-4 chemotaxis in 0.1% BSA/HBSS and in 100% human AB serum (IC50s = 3.5 and 33.4 nM, respectively), as well as chemotaxis of human T cells stimulated by retinoic acid (RA) and mouse and rat thymocytes. Vercirnon binds allosterically to the intracellular side of CCR9 and prevents G protein coupling.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Walters, M.J., Wang, Y., Lai, N., et al. Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease. J. Pharmacol. Exp. Ther. 335(1), 61-69 (2010).

    2. Oswald, C., Rappas, M., Kean, J., et al. Intracellular allosteric antagonism of the CCR9 receptor. Nature 540(7633), 462-465 (2016).