A ferrochetalase inhibitor
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Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate

Item No. 23230

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester
CAS Number
632-93-9
Synonyms
  • DDC
  • 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine
  • NSC 8910
  • NSC 49528
Molecular Formula
C14H21NO4
Formula Weight
267.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2); (1:7): 0.125 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
λmax
233, 350 nm
SMILES
CC1C(C(OCC)=O)=C(C)NC(C)=C1C(OCC)=O
InChi Code
InChI=1S/C14H21NO4/c1-6-18-13(16)11-8(3)12(14(17)19-7-2)10(5)15-9(11)4/h8,15H,6-7H2,1-5H3
InChi Key
CDVAIHNNWWJFJW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe2+ to protoporphyrin IX to create heme B.1 Chronic DDC administration induces Mallory-Denk body formation, a feature of alcoholic and non-alcoholic hepatitis, and reduces IL-12A methylation in mouse liver.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Onisawa, J., and Labbe, R.F. Effects of diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate on the metabolism of porphyrins and iron. The Journal of Biological Chemisty 238(2), 724-727 (1963).

    2. Yuan, Q.X., Marceau, N., French, B.A., et al. Mallory body induction in drug-primed mouse liver. Hepatology 24(3), 603-612 (1996).

    3. Oliva, J., and French, S.W. Changes in IL12A methylation pattern in livers from mice fed DDC. Exp. Mol. Pathol. 92(2), 191-193 (2012).