(+)-Taxifolin (CAS 480-18-2) | Cayman Chemical
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(+)-Taxifolin

Item № 23234
CAS № 480-18-2
Purity ≥95%
product image
                (CAS 480-18-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     25 mg $25.00 0.00
     50 mg $48.00 0.00
     100 mg $90.00 0.00
     500 mg $400.00 0.00

Pricing updated 2018-12-17. Prices are subject to change without notice.

Description
Synonyms
  • (+)-Dihydroquercetin

(+)-Taxifolin is a flavonol with antioxidant activity.1 It increases cell viability of FeCl2 and H2O2-treated bone marrow-derived mesenchymal stem cells (bmMSCs) when used at concentrations ranging from 1 to 100 µg/ml. It also scavenges PTIO radicals in a pH-dependent manner with lower concentrations needed at higher pH (IC50s = 2.6-0.4 mM for pH 5-9, respectively). (+)-Taxifolin protects against H2O2- and xanthine/xanthine oxidase-induced oxidative injury in primary cultured rat cortical cells (IC50 = 7.8 µg/ml) and inhibits lipid peroxidation in rat brain homogenates (IC50 = 1.02 µg/ml).2

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Technical Information
Formal Name
(2R,3R)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
CAS Number
480-18-2
Synonyms
  • (+)-Dihydroquercetin
Molecular Formula
C15H12O7
Formula Weight
304.3
Purity
≥95%
Formulation
A crystalline solid
λmax
291 nm
SMILES
OC1=CC(O)=C(C([C@H](O)[C@@H](C2=CC=C(O)C(O)=C2)O3)=O)C3=C1
InChI Code
InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1
InChI Key
CXQWRCVTCMQVQX-LSDHHAIUSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Li, X., Xie, H., Jiang, Q., et al. The mechanism of (+) taxifolin’s protective antioxidant effect for •OH-treated bone marrow-derived mesenchymal stem cells Cell. Mol. Biol. Lett. 22, 31 (2017).

2. Dok-Go, H., Lee, K.H., Kim, H.J., et al. Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten Brain Res. 965(1-2), 130-136 (2003).

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