A β2-adrenergic receptor agonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Mabuterol

Item No. 23246

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-3-chloro-α-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)-benzenemethanol
CAS Number
56341-08-3
Molecular Formula
C13H18ClF3N2O
Formula Weight
310.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
245, 311 nm
SMILES
ClC1=C(N)C(C(F)(F)F)=CC(C(O)CNC(C)(C)C)=C1
InChi Code
InChI=1S/C13H18ClF3N2O/c1-12(2,3)19-6-10(20)7-4-8(13(15,16)17)11(18)9(14)5-7/h4-5,10,19-20H,6,18H2,1-3H3
InChi Key
JSJCTEKTBOKRST-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $128

    Add

    10 mg

    $219

    Add
    Product Description

    Mabuterol is an agonist of the β2-adrenergic receptor (β2-AR).1,2,3 It induces relaxation of isolated tracheal muscle in guinea pigs and inhibits bronchoconstriction in a guinea pig model of experimental asthma.2 Administration of mabuterol decreases blood pressure and increases heart rate in a dose-dependent manner in rats, cats, and dogs.3 These effects are reversed by the selective β2-AR antagonist ICI 118551 (Item No. 15591), indicating mabuterol is acting at β2-ARs.1 At concentrations ≥1 μM, mabuterol acts as a β1-AR antagonist in isolated dog right atria.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Akahane, K., Furukawa, Y., Ogiwara, Y., et al. β-adrenoceptor blocking effects of a selective β2-agonist, mabuterol, on the isolated, blood-perfused right atrium of the dog. Br. J. Pharmacol. 97(3), 709-716 (1989).

    2. Murai, T., Maejima, T., and Osada, E. Pharmacological studies of mabuterol, a new selective beta 2-stimulant. I: Bronchodilating effect. Arzneimittelforschung 34(11A), 1633-1640 (1984).

    3. Osada, E., Murai, T., Ishizaka, Y., et al. Pharmacological studies of mabuterol, a new selective beta 2-stimulant. II: Effects on the cardiovascular system and smooth muscle organs. Arzneimittelforschung 34(11A), 1641-1651 (1984).