A β2-adrenergic receptor agonist
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Mabuterol

Item No. 23246

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-3-chloro-α-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)-benzenemethanol
CAS Number
56341-08-3
Molecular Formula
C13H18ClF3N2O
Formula Weight
310.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
245, 311 nm
SMILES
ClC1=C(N)C(C(F)(F)F)=CC(C(O)CNC(C)(C)C)=C1
InChi Code
InChI=1S/C13H18ClF3N2O/c1-12(2,3)19-6-10(20)7-4-8(13(15,16)17)11(18)9(14)5-7/h4-5,10,19-20H,6,18H2,1-3H3
InChi Key
JSJCTEKTBOKRST-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $219

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    Product Description

    Mabuterol is an agonist of the β2-adrenergic receptor (β2-AR).1,2,3 It induces relaxation of isolated tracheal muscle in guinea pigs and inhibits bronchoconstriction in a guinea pig model of experimental asthma.2 Administration of mabuterol decreases blood pressure and increases heart rate in a dose-dependent manner in rats, cats, and dogs.3 These effects are reversed by the selective β2-AR antagonist ICI 118551 (Item No. 15591), indicating mabuterol is acting at β2-ARs.1 At concentrations ≥1 μM, mabuterol acts as a β1-AR antagonist in isolated dog right atria.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Akahane, K., Furukawa, Y., Ogiwara, Y., et al. β-adrenoceptor blocking effects of a selective β2-agonist, mabuterol, on the isolated, blood-perfused right atrium of the dog. Br. J. Pharmacol. 97(3), 709-716 (1989).

    2. Murai, T., Maejima, T., and Osada, E. Pharmacological studies of mabuterol, a new selective beta 2-stimulant. I: Bronchodilating effect. Arzneimittelforschung 34(11A), 1633-1640 (1984).

    3. Osada, E., Murai, T., Ishizaka, Y., et al. Pharmacological studies of mabuterol, a new selective beta 2-stimulant. II: Effects on the cardiovascular system and smooth muscle organs. Arzneimittelforschung 34(11A), 1641-1651 (1984).