A selective inhibitor of RIPK3
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GSK872

Item No. 23300

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine
CAS Number
1346546-69-7
Molecular Formula
C19H17N3O2S2
Formula Weight
383.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.15 mg/mlEthanol: 15 mg/ml
λmax
224, 252, 362 nm
SMILES
CC(C)S(C1=CC(C(NC2=CC=C(SC=N3)C3=C2)=CC=N4)=C4C=C1)(=O)=O
InChi Code
InChI=1S/C19H17N3O2S2/c1-12(2)26(23,24)14-4-5-16-15(10-14)17(7-8-20-16)22-13-3-6-19-18(9-13)21-11-25-19/h3-12H,1-2H3,(H,20,22)
InChi Key
ZCDBTQNFAPKACC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    GSK872 is an inhibitor of receptor-interacting protein kinase 3 (RIPK3).1 It is selective for RIPK3, having >1,000-fold selectivity over 300 kinases in a fluorescence polarization assay at a concentration of 1 μM. GSK872 inhibits TNF- and virus-induced necrosis in 3T3-SA fibroblasts. It also inhibits necrosis induced by toll-like receptor 3 (TLR3).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kaiser, W.J., Sridharan, H., Huang, C., et al. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. The Journal of Biological Chemisty 288(43), 31268-31279 (2013).