An antimycobacterial compound
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Labeled Version(s)
28535Clofazimine-d7
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Clofazimine

Item No. 23301

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,5-bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-2-phenazinamine
CAS Number
2030-63-9
Synonyms
  • NSC 141046
Molecular Formula
C27H22Cl2N4
Formula Weight
473.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 1 mg/mlEthanol: 0.2 mg/ml
λmax
285, 452 nm
SMILES
CC(C)/N=C1C=C2N(C3=CC=C(Cl)C=C3)C4=CC=CC=C4N=C2C=C\1NC5=CC=C(Cl)C=C5
InChi Code
InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+
InChi Key
WDQPAMHFFCXSNU-BGABXYSRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Clofazimine is an antimycobacterial compound with MICs ranging from 0.03 to 0.12 μg/ml against clinical isolates of M. paratuberculosis.1 It also has activity against 80 isolates of M. fortuitum, M. chelonae, and M. fallax (MICs = ≤0.25-8 μg/ml).2 Clofazimine (25 mg/kg per day) reduces the number of M. tuberculosis infected cells in the spleen and lungs of mice infected with the multidrug-resistant clinical isolate strain CNL.3 Formulations containing clofazimine have been used for the treatment of leprosy and drug-resistant tuberculosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chiodini, R.J. Bactericidal activities of various antimicrobial agents against human and animal isolates of Mycobacterium paratuberculosis. Antimicrob. Agents Chemother. 34(2), 366-367 (1990).

    2. Ausina, V., Condom, M.J., Mirelis, B., et al. In vitro activity of clofazimine against rapidly growing nonchromogenic mycobacteria. Antimicrob. Agents Chemother. 29(5), 951-952 (1986).

    3. Klemens, S.P., DeStefano, M.S., and Cynamon, M.H. Therapy of multidrug-resistant tuberculosis: Lessons from studies with mice. Antimicrob. Agents Chemother. 37(11), 2344-2347 (1993).