An internal standard for the quantification of clofazimine
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Unlabeled Version(s)
23301Clofazimine
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Clofazimine-d7

Item No. 28535

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(E)-N,5-bis(4-chlorophenyl)-3-((propan-2-yl-d7)imino)-3,5-dihydrophenazin-2-amine
Molecular Formula
C27H15Cl2D7N4
Formula Weight
480.4
Purity
≥99% deuterated forms (d1-d7)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleMethanol: Slightly soluble (heated)
SMILES
ClC(C=C1)=CC=C1NC2=CC3=NC4=CC=CC=C4N(C5=CC=C(Cl)C=C5)C3=C/C2=N\C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H]
InChi Code
InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+/i1D3,2D3,17D
InChi Key
WDQPAMHFFCXSNU-SXUGDVLYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $229

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    Product Description

    Clofazimine-d7 is intended for use as an internal standard for the quantification of clofazimine (Item No. 23301) by GC- or LC-MS. Clofazimine is an antimycobacterial compound with MICs ranging from 0.03 to 0.12 μg/ml against clinical isolates of M. paratuberculosis.1 It also has activity against 80 isolates of M. fortuitum, M. chelonae, and M. fallax (MICs = ≤0.25-8 μg/ml).2 Clofazimine (25 mg/kg per day) reduces the number of M. tuberculosis-infected cells in the spleen and lungs of mice infected with the multidrug-resistant clinical isolate strain CNL.3 Formulations containing clofazimine have been used for the treatment of leprosy and drug-resistant tuberculosis.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chiodini, R.J. Bactericidal activities of various antimicrobial agents against human and animal isolates of Mycobacterium paratuberculosis. Antimicrob. Agents Chemother. 34(2), 366-367 (1990).

    2. Ausina, V., Condom, M.J., Mirelis, B., et al. In vitro activity of clofazimine against rapidly growing nonchromogenic mycobacteria. Antimicrob. Agents Chemother. 29(5), 951-952 (1986).

    3. Klemens, S.P., DeStefano, M.S., and Cynamon, M.H. Therapy of multidrug-resistant tuberculosis: Lessons from studies with mice. Antimicrob. Agents Chemother. 37(11), 2344-2347 (1993).

    4. Szeto, W., Garcia-Buitrago, M.T., Abbo, L., et al. Clofazimine enteropathy: A rare and underrecognized complication of mycobacterial therapy. Open Forum Infect. Dis. 3(3), ofw004 (2016).