An inhibitor of MAIT cell activation
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Acetyl-6-formylpterin

Item No. 23303

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(6-formyl-3,4-dihydro-4-oxo-2-pteridinyl)-acetamide
CAS Number
29769-49-1
Synonyms
  • Ac-6-FP
  • 2-Acetamido-6-formylpteridin-4-one
  • NSC 129965
Molecular Formula
C9H7N5O3
Formula Weight
233.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 0.1 mg/ml
λmax
284 nm
SMILES
CC(NC(N1)=NC(N=CC(C=O)=N2)=C2C1=O)=O
InChi Code
InChI=1S/C9H7N5O3/c1-4(16)11-9-13-7-6(8(17)14-9)12-5(3-15)2-10-7/h2-3H,1H3,(H2,10,11,13,14,16,17)
InChi Key
DDBCPKAHJKOGKK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $390

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    Cayman Chemical
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    Product Description

    Acetyl-6-formylpterin is an inhibitor of mucosal-associated invariant T (MAIT) cell activation.1 It dose-dependently increases the surface expression of MHC-related 1 (Mr1) in WT3 cells overexpressing Mr1 (WT3-m) following incubation with E. coli but does not activate MAIT cells cocultured with WT3-m cells when used at concentrations ranging from 0.23-15 µM. Acetyl-6-formylpterin is also a degradation product of folic acid (Item No. 20515) and a precursor in the synthesis of 2’-hydroxy-7,8-dihydrofolate, which is a metabolite of para-aminosalicylic acid (PAS) in M. tuberculosis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Soudais, C., Samassa, F., Sarkis, M., et al. In vitro and in vivo analysis of the gram-negative bacteria-derived riboflavin precursor derivatives activating mouse MAIT cells. J. Immunol. 194(10), 4641-4649 (2015).

    2. Dawadi, S., Kordus, S.L., Baughn, A.D., et al. Synthesis and analysis of bacterial folate metabolism intermediates and antifolates. Org. Lett. 19(19), 5220-5223 (2017).