A glucocorticoid receptor agonist
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Loteprednol etabonate

Item No. 23305

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(11β,17α)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-androsta-1,4-diene-17-carboxylic acid, chloromethyl ester
CAS Number
82034-46-6
Molecular Formula
C24H31ClO7
Formula Weight
467.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.2 mg/ml
λmax
245 nm
SMILES
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(OC(OCC)=O)C(OCCl)=O)=C1
InChi Code
InChI=1S/C24H31ClO7/c1-4-30-21(29)32-24(20(28)31-13-25)10-8-17-16-6-5-14-11-15(26)7-9-22(14,2)19(16)18(27)12-23(17,24)3/h7,9,11,16-19,27H,4-6,8,10,12-13H2,1-3H3/t16-,17-,18-,19+,22-,23-,24-/m0/s1
InChi Key
DMKSVUSAATWOCU-HROMYWEYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $41

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    10 mg

    $75

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    25 mg

    $178

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    50 mg

    $312

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    Product Description

    Loteprednol etabonate is a glucocorticoid receptor agonist with an affinity 4.3 times that of dexamethasone (Item No. 11015).1 It decreases wound healing time in mice and minimizes scarring of rabbit cornea wounds.2,3 Formulations containing loteprednol etabonate are used in the treatment of inflammatory eye conditions.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Druzgala, P., Hochhaus, G., and Bodor, N. Soft drugs--10. Blanching activity and receptor binding affinity of a new type of glucocorticoid: loteprednol etabonate. J. Steroid Biochem. Mol. Biol. 38(2), 149-154 (1991).

    2. Bodor, N.S., Kiss-Buris, S.T., and Buris, L. Novel soft steroids: Effects on cell growth in vitro and on wound healing in the mouse. Steroids 56(8), 434-439 (1991).

    3. Bodor, N., and Varga, M. Effect of a novel soft steroid on the wound healing of rabbit cornea. Exp. Eye Res. 50(2), 183-187 (1990).