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WAY-200070

Item № 23323
CAS № 440122-66-7
Purity ≥98%
product image
                (CAS 440122-66-7)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $58.00 0.00
     10 mg $109.00 0.00
     25 mg $247.00 0.00
     50 mg $406.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • WAY-00005

WAY-200070 is a potent and selective agonist of estrogen receptor β (ERβ; IC50s = 2 and 187 nM for human full-length ERβ and ERα, respectively).1 WAY-200070 (30 mg/kg, s.c. in mice) induces nuclear translocation of ERβ and increases c-fos activation and dopamine levels in the striatum four hours after administration.2 At the same dose, it decreases depressive-like behavior in the tail suspension test. It has anxiolytic effects in mice using the four-plate and stress-induced hyperthermia tests and in zebrafish larvae using a light-dark choice behavior test.2,3 In addition, WAY-200070 improves glucose and insulin sensitivity in mouse models of diabetes.4

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Technical Information
Formal Name
7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol
CAS Number
440122-66-7
Synonyms
  • WAY-00005
Molecular Formula
C13H8BrNO3
Formula Weight
306.1
Purity
≥98%
Formulation
A crystalline solid
λmax
289, 324 nm
SMILES
OC1=CC(Br)=C2C(N=C(C3=CC=C(O)C=C3)O2)=C1
InChI Code
InChI=1S/C13H8BrNO3/c14-10-5-9(17)6-11-12(10)18-13(15-11)7-1-3-8(16)4-2-7/h1-6,16-17H
InChI Key
BAAILVWEAXFTSF-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Malamas, M.S., Manas, E.S., McDevitt, R.E., et al. Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands J. Med. Chem. 47(21), 5021-5040 (2004).

2. Hughes, Z.A., Liu, F., Platt, B.J., et al. WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent Neuropharmacology 54(7), 1136-1142 (2008).

3. F., C., Chen, S., Liu, S., et al. Effects of lorazepam and WAY-200070 in larval zebrafish light/dark choice test Neuropharmacology 95, 226-233 (2015).

4. Alonso-Magdalena, P., Ropero, A.B., García-Arévalo, M., et al. Antidiabetic actions of an estrogen receptor β selective agonist Diabetes 62(6), 2015-2025 (2013).

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