Pricing updated 2019-07-23. Prices are subject to change without notice.
WAY-200070 is a potent and selective agonist of estrogen receptor β (ERβ; IC50s = 2 and 187 nM for human full-length ERβ and ERα, respectively).1 WAY-200070 (30 mg/kg, s.c. in mice) induces nuclear translocation of ERβ and increases c-fos activation and dopamine levels in the striatum four hours after administration.2 At the same dose, it decreases depressive-like behavior in the tail suspension test. It has anxiolytic effects in mice using the four-plate and stress-induced hyperthermia tests and in zebrafish larvae using a light-dark choice behavior test.2,3 In addition, WAY-200070 improves glucose and insulin sensitivity in mouse models of diabetes.4
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Malamas, M.S., Manas, E.S., McDevitt, R.E., et al. Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-
Hughes, Z.A., Liu, F., Platt, B.J., et al. WAY-
F., C., Chen, S., Liu, S., et al. Effects of lorazepam and WAY-