A TNK2 inhibitor
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XMD16-5

Item No. 23353

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,11-dihydro-2-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
CAS Number
1345098-78-3
Molecular Formula
C23H24N6O2
Formula Weight
416.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 33 mg/mlDMSO:PBS (pH 7.2) (1:7): 0.125 mg/ml
λmax
297 nm
SMILES
OC1CCN(C2=CC=C(NC3=NC=C(NC(C(C=CC=C4)=C4N5C)=O)C5=N3)C=C2)CC1
InChi Code
InChI=1S/C23H24N6O2/c1-28-20-5-3-2-4-18(20)22(31)26-19-14-24-23(27-21(19)28)25-15-6-8-16(9-7-15)29-12-10-17(30)11-13-29/h2-9,14,17,30H,10-13H2,1H3,(H,26,31)(H,24,25,27)
InChi Key
AGLKBEPKKDHHKY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    XMD16-5 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2; IC50 = 0.38 µM), which contains mutations in certain cancer cells.1 It also decreases viability of Ba/F3 cells expressing the oncogenic TNK2 D163E and R806Q mutant proteins (IC50s = 16 and 77 nM, respectively) without affecting viability of parental cell lines up to a concentration of approximately 1 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maxson, J.E., Abel, M.L., Wang, J., et al. Identification and characterization of tyrosine kinase nonreceptor 2 mutations in leukemia through integration of kinase inhibitor screening and genomic analysis. Cancer Res. 76(1), 127-138 (2016).