A sulfated CCK peptide
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CCK Octapeptide (sulfated) (sodium salt)

Item No. 23371

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-L-methionine-3-10-caerulein, sodium salt
Synonyms
  • CCK-8S
  • Cholecystokinin (26-33)
  • SQ 19,844
  • Sincalide
Molecular Formula
C49H62N10O16S3 • XNa
Formula Weight
1143.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
282 nm
SMILES
O=C(N[C@@H](CCSC)C(NCC(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@H](C(N)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)[C@@H](NC([C@@H](N)CC(O)=O)=O)CC4=CC=C(OS(O)(=O)=O)C=C4.[Na]
InChi Code
InChI=1S/C49H62N10O16S3.Na/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27;/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74);/t32-,34-,35-,36-,37-,38-,39-;/m0./s1
InChi Key
JYJSMHUWIFYYOB-ITZXPNBCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $90

    Add

    1 mg

    $132

    Add

    5 mg

    $609

    Add
    Product Description

    Cholecystokinin (CCK) octapeptide is a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.1,2 It is a cleaved product of the full CCK preprohormone that is more potent than the full length enzyme in stimulating contraction of guinea pig gallbladder but with a shorter duration.2,3 CCK octapeptide (sulfated) is 300-fold more active than the non-sulfated CCK octapeptide (Item No. 24404).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Raybould, H.E., and Lloyd, K.C. Integration of postprandial function in the proximal gastrointestinal tract. Role of CCK and sensory pathways. Ann. N. Y. Acad. Sci. 713(1), 143-156 (1994).

    2. Ondetti, M.A., Pluščec, J., Sabo, E.F., et al. Synthesis of cholecystokinin-pancreozymin. I. The C-terminal dodecapeptide. J. Am. Chem. Soc. 92(1), 195-199 (1970).

    3. Rubin, B., Engel, S.L., Drungis, A.M., et al. Cholecystokinin-like activities in guinea pigs and in dogs of the C-terminal octapeptide (SQ 19,844) of cholecystokinin. J. Pharm. Sci. 58(8), 955-959 (1969).