The C-5 glycoside isomer of uridine
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β-Pseudouridine

Item No. 23383

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione
CAS Number
1445-07-4
Synonyms
  • NSC 162405
  • 5-Ribosyluracil
Molecular Formula
C9H12N2O6
Formula Weight
244.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
208, 265 nm
SMILES
O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C(C(N2)=O)=CNC2=O
InChi Code
InChI=1S/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1
InChi Key
PTJWIQPHWPFNBW-GBNDHIKLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $107

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    10 mg

    $193

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    25 mg

    $424

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    Product Description

    β-Pseudouridine is the C-5 glycoside isomer of the nucleoside uridine (Item No. 20300).1 It is formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme. β-pseudouridine is found in tRNAs from bacteria, archaea, and eukaryotes.2 In vitro, it reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hamma, T., and Ferré-D'Amaré, A.R. Pseudouridine synthases. Chem. Biol. 13(11), 1125-1135 (2006).

    2. Lorenz, C., Lünse, C.E., and Mörl, M. tRNA modifications: Impact on structure and thermal adaptation. Biomolecules 7(2), E35 (2017).

    3. Monobe, M., Arimoto-Kobayashi, S., and Ando, K. β-pseudouridine, a beer component, reduces radiation-induced chromosome aberrations in human lymphocytes. Mutat. Res. 538(1-2), 93-99 (2003).