A natural steroid glycoside with diverse effects
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20(S)-Ginsenoside Rh2

Item No. 23390

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
12β,20-dihydroxydammar-24-en-3β-yl, β-D-glucopyranoside
CAS Number
78214-33-2
Synonyms
  • 20(S)-Ginsenoside Rh2
Molecular Formula
C36H62O8
Formula Weight
622.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@](O)(C)CC/C=C(C)/C)(C)[C@]3(C)CC[C@]4([H])[C@@](CC[C@H](O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)C4(C)C)(C)[C@@]3([H])C1
InChi Code
InChI=1S/C36H62O8/c1-20(2)10-9-14-36(8,42)21-11-16-35(7)27(21)22(38)18-25-33(5)15-13-26(32(3,4)24(33)12-17-34(25,35)6)44-31-30(41)29(40)28(39)23(19-37)43-31/h10,21-31,37-42H,9,11-19H2,1-8H3/t21-,22+,23+,24-,25+,26-,27-,28+,29-,30+,31-,33-,34+,35+,36-/m0/s1
InChi Key
CKUVNOCSBYYHIS-IRFFNABBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $54

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    5 mg

    $209

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    10 mg

    $315

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    25 mg

    $717

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    Cayman Chemical
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    Product Description

    Ginsenoside Rh2 is a steroid glycoside found in plants of the genus Panax that has diverse biological activities.1,2,3,4,5 It inhibits release of β-hexosaminidase from RBL-2H3 cells (IC50 = 100 μM) and inhibits the IgE-dependent passive cutaneous anaphylaxis reaction in mice at a dose of 25 mg/kg.1 It inhibits growth of HRA ovarian and BxPC-3 pancreatic cancer cells in a dose-dependent manner.3,4 In vivo, ginsenoside Rh2 decreases immobility time in the forced swim test in a mouse model of colorectal carcinoma.5 Ginsenoside Rh2 also reduces infarct volume in a rat model of ischemia-reperfusion-induced brain injury.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Park, E.-K., Choo, M.-K., Kim, E.-J., et al. Antiallergic activity of ginsenoside Rh2. Biol. Pharm. Bull. 26(11), 1581-1584 (2003).

    2. Park, E.-K., Choo, M.-K., Oh, J.K., et al. Ginsenoside Rh2 reduces ischemic brain injury in rats. Biol. Pharm. Bull. 27(3), 433-436 (2004).

    3. Kikuchi, Y., Sasa, H., Kita, T., et al. Inhibition of human ovarian cancer cell proliferation in vitro by ginsenoside Rh2 and adjuvant effects to cisplatin in vivo. Anticancer Drugs 2(1), 63-67 (1991).

    4. Tang, X.-P., Tang, G.-D., Fang, C.-Y., et al. Effects of ginsenoside Rh2 on growth and migration of pancreatic cancer cells. World J. Gastroenterol. 19(10), 1582-1592 (2013).

    5. Wang, J., Chen, Y., Dai, C.L., et al. Ginsenoside Rh2 alleviates tumor-associated depression in a mouse model of colorectal carcinoma. Am. J. Transl. Res. 8(5), 2189-2195 (2016).