A metabolite of ginsenoside Rb1 with diverse biological activity
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Ginsenoside CK

Item No. 29926

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,12β)-3,12-dihydroxydammar-24-en-20-yl, β-D-glucopyranoside
CAS Number
39262-14-1
Synonyms
  • Ginsenoside Compound K
  • Ginsenoside IH901
Molecular Formula
C36H62O8
Formula Weight
622.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)(C)[C@]4(C)CC[C@]5([H])[C@@](CC[C@H](O)C5(C)C)(C)[C@@]4([H])C1
InChi Code
InChI=1S/C36H62O8/c1-20(2)10-9-14-36(8,44-31-30(42)29(41)28(40)23(19-37)43-31)21-11-16-35(7)27(21)22(38)18-25-33(5)15-13-26(39)32(3,4)24(33)12-17-34(25,35)6/h10,21-31,37-42H,9,11-19H2,1-8H3/t21-,22+,23+,24-,25+,26-,27-,28+,29-,30+,31-,33-,34+,35+,36-/m0/s1
InChi Key
FVIZARNDLVOMSU-IRFFNABBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $54

    Add

    10 mg

    $91

    Add

    25 mg

    $197

    Add

    50 mg

    $341

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Ginsenoside CK is a metabolite of the saponin ginsenoside Rb1 (Item No. 15319) that has diverse biological activities.1,2,3,4 Ginsenoside CK is formed from ginsenoside Rb1 via intestinal bacterial exo-β-D-glucosidase.1 It reduces protein levels of matrix metalloproteinase-2 (MMP-2) and pro-MMP-9 in, and inhibits growth, adhesion, and invasion of, MHCC97-H human hepatocellular carcinoma cells (HCCs) when used at concentrations of 50 and 75 µM.2 It inhibits metastasis in an MHCC97-H mouse xenograft model but does not reduce tumor growth. Ginsenoside CK reduces the percentage of memory B cells in the spleen, the number of swollen joints, and lymph node hyperplasia in an adjuvant-induced model of rheumatoid arthritis.3 It increases the activity of pSer9-glycogen synthase kinase and insulin degrading enzyme (IDE) and reduces the accumulation of amyloid-β (1-42) (Aβ42; Item No. 20574) in the rat hippocampal CA1 and CA3 regions in a model of vascular dementia induced by chronic cerebral hypofusion.4 It also increases the percentage of time spent in the target quadrant of the Morris water maze when administered at doses of 100 and 200 mg/kg in the same model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jung, I.-H., Lee, J.H., Hyun, Y.-J., et al. Metabolism of ginsenoside Rb1 by human intestinal microflora and cloning of Its metabolizing β-D-glucosidase from Bifidobacterium longum H-1. Biol. Pharm. Bull. 35(4), 573-581 (2012).

    2. Ming, Y., Z., C., Chen, L., et al. Ginsenoside compound K attenuates metastatic growth of hepatocellular carcinoma, which Is associated with the translocation of nuclear factor-κB p65 and reduction of matrix metalloproteinase-2/9. Planta Med. 77(5), 428-433 (2011).

    3. Chen, J., Wang, Q., Wu, H., et al. The ginsenoside metabolite compound K exerts its anti-inflammatory activity by downregulatingmemory B cell in adjuvant-induced arthritis. Pharm. Biol. 54(7), 1280-1288 (2016).

    4. Zong, W., Zeng, X., Chen, S., et al. Ginsenoside compound K attenuates cognitive deficits in vascular dementia rats by reducing the Aβ deposition. J. Pharmacol. Sci. 139(3), 223-230 (2019).